Can Serum Biomarker of Plaque Vulnerability be Identified Through the Contrast-enhanced Ultrasound of Carotid Artery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Peak plasma concentration of Biomarker that is statistically significant different according to the presence of intraplaque neovascularization on contrast enhanced ultrasound of carotid artery
研究概览
简要总结
No serum biomarker has qualified for clinical use until now. However several biomarkers, especially markers of inflammatory or proteolytic activity seem to promising in the identification of vulnerable plaques. Moreover, recent study confirmed that contrast-enhanced ultrasound imaging(CEUS) can visualize intraplaque neovascularization and represent the plaque vulnerability. In this study we try to identify indicators through analysis of the relationship between plaque neovascularization seen by CEUS and well known biomarkers such as serum matrix metalloproteinase(MMP)-2, MMP-9, cathepsin family(L,S,V), cystatin C, lipoprotein phospholipase A2, and hs-crp
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with carotid plaques size more than 2mm by carotid ultrasound
排除标准
- •known allergy to albumin, or to the ultrasound contrast agent
- •the patients with history of carotid endarterectomy and carotid stent
- •acute myocardial infarction, cardiogenic shock
- •connective tissue disease and malignancy
- •creatinine clearance lower than 30ml/min and the history of dialysis
结局指标
主要结局
Peak plasma concentration of Biomarker that is statistically significant different according to the presence of intraplaque neovascularization on contrast enhanced ultrasound of carotid artery
时间窗: after performing contrast enhanced ultrasound of carotid artery, upto 3 hospital days
次要结局
- the number of the patients with history of cardiovascular event including myocardial infarction, cerebral vascular event and peripheral arterial disease and the number of 1 year clinical outcome of cardiovascular event(after performing contrast enhanced ultrasound of carotid artery, upto 1 year clinical follow up)
研究者
Weon Kim
Assoiciate Professor
Kyunghee University Medical Center