The Remeasure Trial

Not Applicable

Completed

• Conditions: Ileocolic Crohn Disease; Resection of the Mesentery; Kono S Anastomosis

• Registration Number: NCT07164209
• Lead Sponsor: Azienda Ospedaliera Ordine Mauriziano di Torino

Brief Summary

Aim of the present study is to compare a stapled, functional end-to-end, ileo-colic anastomosis with removal of the mesentery vs the manual, functional end-to-end, ileo-colic Kono-S anastomosis with mesentery preservation, in terms of peri-operative safety, and efficacy in preventing endoscopic recurrence after ileocolic resection for Crohn Disease. Patients presenting with ileocolic primary Crohn disease either not suitable for medical treatment or with contraindications for therapy i.e: occlusion, abscess, contraindications to the use of biologics

Detailed Description

Patients who meet inclusion criteria will be randomized between two surgical procedures:

The excision of the mesentery (group A) and ileocolic anastomosis and the Kono-S anastomosis (group B) after ileocolic or ileo-cecal resection. The operation could be performed with open or laparoscopic approach.

Excision of the mesentery:

the mesentery is fully dissected and excised to the limit of macroscopic "fat wrapping", where mesenteric fat is inflamed and extends beyond its normal anatomical distribution over the surface of the contiguous intestine. The anastomosis between colon and ileum is than performed mechanically end to end.

Kono-S anastomosis:

the mesentery is not removed but cutted close to the bowel. The bowel is then divided transversely by placing a linear stapler perpendicular to the intestinal lumen and the mesentery. The corners of the two staple lines are reinforced and the two stumps are approximated using 5-7 sutures to create the column.

If the caliber of the two intestinal segments differs significantly, the sutures should be spaced to evenly distribute the surplus tissue of the larger segment, in order to achieve good approximation and stable support for the anastomosis. To create the anastomosis, an antimesenteric longitudinal enterotomy (or colostomy) is performed on each stump to allow a transverse lumen of 7 cm in diameter for the small bowel or closer to 8 cm for the colon. In this way the supporting column is located immediately behind the posterior wall of the anastomosis providing a rigid and stable support to prevent mechanical deformation and functional constriction of the lumen of the anastomosis.

Study Timeline

• Study Start: 2022-01-02
• Primary Completion: 2024-12-30
• Study Completion: 2024-12-31
• Status Verified: 2025-09
• Study First Submitted: 2025-09-02
• Study First Submitted QC: 2025-09-02
• Last Update Submitted: 2025-09-02
• Study First Posted: 2025-09-10
• Last Update Posted: 2025-09-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 73

Inclusion Criteria

• • Patients > 18 years

  • Histological diagnosis of Crohn's Disease
  • Patient's ability to read and understand the documentation concerning the study and the Informed consent
  • Ileocolic disease requiring resection

Exclusion Criteria

• Older than 70

  • Recurrent disease, previous surgery for CD
  • Gastroenterologists or patients not willing to maintain a drug washout for six months
  • Emergency surgery

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
endoscopic recurrence (Rutgeerts score i2 or greater) at 6,12, 18 months.Endoscopic recurrence was defined if Rutgeerts > i2 (>5 aphthous lesions or larger lesions confined to anastomosis), i3 (diffuse ileitis), or i4 (diffuse inflammation with large ulc	From the treatment a close follow up is performed at 6, 12 and 18 months.The majority of endoscopic examinations were centrally performed. In few cases check was performed in separated centers and a "recording video clip" of the endoscopy was assessed fo

Trial Locations

Locations (1)

Dott Lucia Borsotti is the head of the experimetal Office in Azienda Sanitaria Ospedaliera Ordine Mauriziano and could answer about enrolling of patients and submission of the protocol to the ethicl Commette of Città della Salute e della Scienza of Torin; 🇮🇹 Torino, To, Italy