Exploratory Study of the Relationships Between the Biomarkers of Inflammation, Lipidome and Insulin Resistance and Disorders of Glycemic Regulation in a Cohort of Insulin-resistant Subjects Due to Excess Weight or Dunnigan's Lipodystrophy
- Conditions
- LipodystrophyDunnigan Syndrome
- Interventions
- Other: research-specific blood sample
- Registration Number
- NCT05424913
- Lead Sponsor
- Centre Hospitalier Universitaire de la Réunion
- Brief Summary
The objective of this work is to identify biomarkers of interest in patients with insulin resistance leading to early disorders of glycemic regulation. For this the investigators want to assay the insulin resistance marker Insulin Regulated Amino Peptidase serique (IRAPs), the plasma lipidome and inflammation markers in 2 populations of insulin-resistant subjects due to Dunnigan's inherited lipodystrophy or overweight/obesity and insulin-sensitive subjects with or without a glycemic regulation disorder objectified during an Oral induced hyperglycemia. The results of the IRAPs, lipidome and inflammation assays will be compared in insulin-resistant subjects, between normoglycemic, prediabetic and diabetic subjects. Correlations will be made between these markers and the deterioration of glycemic regulation as well as with known insulin resistance parameters (HOmeostasis Assessment Model (HOMA), Quantitative Insulin-sensitivity Check Index (QUICKI),Insulin Sensitivity Index (Isi) MATSUDA).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 150
- Subjects with Dunnigan's Lipodystrophy OR Non-lipodystrophic insulin-resistant subjects OR Insulin-sensitive non-lipodystrophic subjects
- major
- Subjects benefiting from metabolic exploration in the Endocrinology, Diabetology and Nutrition department of the Reunion University Hospital.
- Subject benefiting from an oral glucose tolerance test (OGTT) during his follow-up in the Endocrinology, Diabetology and Nutrition department of the Reunion University Hospital.
- Person affiliated or beneficiary of a social security scheme.
- Subject having been informed of the study in progress and having given their written consent.
- Pregnant woman
- Person under guardianship or curators or deprived of liberty
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Insulin-sensitive non-lipodystrophic subjects research-specific blood sample - Subjects with Dunnigan's Lipodystrophy research-specific blood sample - Non-lipodystrophic insulin-resistant subjects research-specific blood sample -
- Primary Outcome Measures
Name Time Method Insulin Regulated Amino Peptidase sérique (IRAPs) levels at inclusion Insulin Regulated Amino Peptidase sérique (IRAPs)
inflammation markers levels at inclusion TNF-α (tumor necrosis factors-α), IL-1β (interleukin-1β), IL-2, IL-6, IL-18, IFN-γ (interferon-γ) et MCP-1 (monocyte chemoattractant protein-1), IL-10, IL-4, IL-5
lipidome markers levels at inclusion 662 plasma lipid species
- Secondary Outcome Measures
Name Time Method Compare levels of inflammation markers between the 3 categories of participants at inclusion TNF-α (tumor necrosis factors-α), IL-1β (interleukin-1β), IL-2, IL-6, IL-18, IFN-γ (interferon-γ) et MCP-1 (monocyte chemoattractant protein-1), IL-10, IL-4, IL-5
Compare levels of lipidome markers between the 3 categories of participants at inclusion 662 plasma lipid species
Compare levels of Insulin Regulated Amino Peptidase sérique (IRAPs) between the 3 categories of participants at inclusion Insulin Regulated Amino Peptidase sérique (IRAPs)
Trial Locations
- Locations (1)
CHU de la Réunion
🇷🇪Saint-Pierre, Réunion