BRIDGE study;BRain Imaging, Development & GEnetics

Recruiting

• Conditions: stemmingsstoornissen; brainfunction; psychosis; 10039628

• Registration Number: NL-OMON50654
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 220

Inclusion Criteria

All subjects have to satisfy the following criteria in order to participate in
the study at baseline:
- Between 8-18 years of age
- provide written informed consent (by child and parent)
- do not have a major medical history
- dutch speaking
- IQ > 70Specific for offspring of SZ and BD (n =160 in each group):
- at least one parent or sibling with a SZ or BD or,
- two 2nd degree relatives with BD or SZ
Additional criteria for MRI group (n=80 in SZ-group and n=120 in BD-group) of
at risk offspring
- do not use psychotropic medication
- do not have ferrous objects in or around the body (e.g. braces, glasses,
metal fragments)
- do not have a history of epilepsy in first-degree relatives
- no claustrophobiaSpecific for healthy subjects (n =80):
- do not have a history of psychiatric illness
- do not have a parent or a first-degree family member with a psychotic and/or
mood disorder or other psychiatric illness
- do not use psychotropic medication
- do not have ferrous objects in or around the body (e.g. braces, glasses,
metal fragments)
- do not have a history of epilepsy in first-degree relatives
- no claustrophobia

Exclusion Criteria

Exclusion criteria
- not dutch speaking
- history of closed- or open-head injury
- history of neurological illness
- IQ < 70
- major medical history
- history of epilepsy
- history of epilepsy in first degree relatives

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified