BRIDGE - Parental and Offspring Brain Imaging in families at risk for severe mental illness

Recruiting

Conditions: psychische stoornissen: bipolaire stoornis
Bipolar disorder
manic-depressive disorder
Schizophrenia
Schizophrenic disorder
10039628

Registration Number: NL-OMON53543

Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 400

Inclusion Criteria

Previously-included offspring: All offspring who participated in the BRIDGE
cohort are eligible for inclusion in this MRI study. Offspring will now be 14
years and older. The only other inclusion criterion is ability to provide
informed consent.
Parents: All biological parents of offspring who participated in the BRIDGE
cohort are eligible for inclusion in this MRI study. The only other inclusion
criterion is ability to provide informed consent.
Newly-included offspring: All biological offspring who did not previously
participate in the BRIDGE cohort are eligible for inclusion in this MRI study.
As this will be their first assessment, subjects will have to satisfy the
following criteria in order to participate in the study:

-from 8 years and older
-provide written informed consent (by child and/or parents)
-Dutch speaking
- IQ > 70

Exclusion Criteria

Previously-included offspring, newly-included offspring, and parents:
- contraindication for MRI (including claustrophobia, a cardiac implantable
electronic device, ferromagnetic metal implants, piercing (in some cases),
tattoos (in some cases)) (Ghadimi & Sapra, 2022);
- not having given permission to be approached for further research during an
earlier assessment.
- history of closed- or open-head injury
- history of neurological illness
- major medical history
- history of epilepsy

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Brain volume, cortical thickness, cortical surface, curvature/gyrification<br /><br>metrics (global measures and local regions) from T1 weighted images.<br /><br>- Fractional anisotrophy, mean diffusivity, axial diffusivity, radial<br /><br>diffusivity (per fiber and voxelbased) from DTI images.<br /><br>- Brain activation during resting state (per region and voxelbased) from rsfMRI<br /><br>images.<br /><br>- Graph theory metrics from FA (DTI) and resting state brain activation<br /><br>(rsfMRI).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The following variables are seen as possible confounding or modifying factors:<br /><br>- sex and age<br /><br>- age of onset parental and offspring disorder<br /><br>- marital and/or household status of parents<br /><br>- income and educational level of parents<br /><br>- parental psychosis, depression, and/or mania diagnoses and symptoms<br /><br>- medication use<br /><br>- handedness</p><br>