on-invasive characterization of paediatric brain tumours using metabolic imaging at high magnetic field
- Conditions
- ow grade glioma (LGG) and diffuse pontine glioma (DIPG)
- Registration Number
- NL-OMON24537
- Lead Sponsor
- MC Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 25
Inclusion Criteria
Children, 5-18 years diagnosed with a possible low grade glioma (LGG) or diffuse pontine glioma (DIPG)
-Children must be able to undergo MRI without anaesthesia;
-Informed and having given informed consent (either by patient and / or parents / legal guardian).
Exclusion Criteria
-The presence of claustrophobia;
-Patients from who it is known at the time of inclusion that they will undergo tumour resection within 1 month;
-MRI-specific exclusion criteria, such as metal implants. Screening for MRI specific exclusion criteria will be done using the regular MRI (at 7 Tesla) safety screening.
-Refusal or inability to provide informed consent by patient and / or parent / legal guardian.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine whether metabolic imaging at 7 Tesla is feasible and suitable to detect <br>changes in phospholipids and APT levels in paediatric brain tumours<br>
- Secondary Outcome Measures
Name Time Method ·To investigate the use of non-invasive metabolic imaging to evaluate treatment effects of paediatric brain tumours;<br>·To investigate the use of non-invasive metabolic imaging to evaluate aggressiveness of paediatric brain tumours and if available compare it with histology and molecular biology<br>