Viral and Host Factors in the Transmission and Pathogenesis of HIV
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- HIV Infections
- Sponsor
- Rockefeller University
- Enrollment
- 600
- Locations
- 2
- Primary Endpoint
- Participants are tested for HIV-1 RNA levels, the presence of antibodies to HIV antigens, and T cell subsets
- Status
- Terminated
- Last Updated
- 7 years ago
Overview
Brief Summary
To study the collection of blood from individuals known to be at high risk for HIV-infection or who have been recently infected with HIV.
The data collected are used for diagnostic, prognostic and management decisions as outlined by current HIV-1 Treatment Guidelines.
Detailed Description
This phlebotomy protocol permits the collection of blood from individuals known to be at high risk for HIV-infection or who have been recently infected with HIV. Participants will have from 10 to 60 ml (approximately 1 to 4 tablespoons) of blood drawn for one or all of the following tests: * T cell subset enumeration * Serologic reactivity with HIV antigens * Viral load assays by bDNA, PCR, or RT-PCR * Routine Laboratory assessments (chemistries, liver function tests, hepatitis serology, RPR) * HIV-1 Resistance Testing These data are used for diagnostic, prognostic and management decisions as outlined by current HIV-1 Treatment Guidelines
Investigators
Eligibility Criteria
Inclusion Criteria
- •recently infected with HIV-1 HIV-1 negative, and at high risk for infection
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Participants are tested for HIV-1 RNA levels, the presence of antibodies to HIV antigens, and T cell subsets
Time Frame: first visit
Secondary Outcomes
- Data will be used for diagnostic, prognostic and management decisions as outlined by current HIV-1 Treatment(first visit)