Velocity Vector Imaging in Patients With Moderate-to-Severe Aortic Regurgitation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Velocity Vector Imaging derived segmental systolic peak Strain and Strain rates
研究概览
简要总结
Velocity Vector Imaging may provide reliable and detailed information on left ventricular segmental function in asymptomatic patients with moderate-to severe AR. This may help to identify subclinical myocardial dysfunction in order to operate early enough to prevent postoperative heart failure and restrict unnecessary early operation which could be associated with operative risks and mortality related to prosthetic valves.
详细描述
Chronic aortic regurgitation (AR) is a progressive process which causes both left ventricular volume and pressure overload. While the volume overload is associated with the degree of the aortic regurgitant volume, the pressure overload occurs as a result of systemic hypertension developed due to increased stroke volume. In early stages, excentric hypertrophy occurs aiming to compensate the volume overload in the left ventricle. Therefore , ejection fraction remains in normal range despite the increasing volume overload. Left ventricular dilatation and impairment in ejection fraction only occur in the end stages of the disease. Asymptomatic patients with chronic aortic regurgitation (AR) have a good prognosis in the presence of preserved systolic function. Therefore it is a challenge to identify patients with subclinical left ventricular (LV) dysfunction. Velocity vector imaging (VVI) is a new echocardiographic method based on two dimensional gray scale imaging, which is angle independent and can provide more accurate data about cardiac function.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Moderate-to-severe aortic regurgitation identified by Standard echocardiography.
- •Chronic isolated aortic regurgitation
- •Being asymptomatic ( Class 1 according to NYHA)
- •Sinusal rhythm
排除标准
- •Ejection fraction < 50%
- •Mitral valve disease accompanied to aortic regurgitation (patients with over mild degree of mitral regurgitation and stenosis
- •Aortic stenosis
- •Previous myocardial infarction, or the patients with >50% coronary occlusion in any of the coronary arteries.
- •Cardiomyopathies
- •AV conduction disorders
- •Chronic renal or hepatic insufficiency
- •Malignities
结局指标
主要结局
Velocity Vector Imaging derived segmental systolic peak Strain and Strain rates
时间窗: April 2008
次要结局
未报告次要终点
