Trigeminovascular effects of propranolol in migraine treatment
- Conditions
- Migraine10019231
- Registration Number
- NL-OMON43388
- Lead Sponsor
- Inwendige Geneeskunde
- Brief Summary
Trial is onging in other countries
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 22
Age between 18 and 64 years
Non-smoking for more than 6 months
Females should use an oral contraceptive pill
Body mass index between 19 and 28 kg/m^2
Capable and willing to give informed consent
General good health, based on medical history and physical examination
History of cardiovascular disease
History of migraine
Previous history of asthma or use of bronchodilators.
Blood pressure <110 systolic (sitting)
Heart rate <60 bpm
Perimenopausal status of females
Any serious illness that can compromise study participation
Use of any medication (e.g., NSAIDs, other analgesics) < 48 hrs before the study, as well as during the study.
Dermal diseases at the upper frontal side of the face
Pregnancy or breastfeeding
History of sensitivity to the fruits of capsicum plants (e.g. chilli peppers)
Alcohol or drug abuse
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Changes in dermal blood flow response to capsaicin application and saline<br /><br>iontophoresis, after propranolol intake.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Changes in blood pressure after propranolol use.</p><br>