Bioavailability of Micronutrients in young and old participants

Not Applicable

• Conditions: K90.9; E63.9; Intestinal malabsorption, unspecified; Nutritional deficiency, unspecified

• Registration Number: DRKS00023858
• Lead Sponsor: Initiator: Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-06-22
• Study Completion: 2022-12-16
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

healthy men and women aged 20 to 35 years (= young group) and healthy men and women aged 60 to 75 years (=old goup). BMI between 19 and 29 kg/m².

Exclusion Criteria

- regular intake of dietary supplements (multivitamins, carotenoids, trace elements) if subjects are not willing to abstain 3 days before intervention
- Active smokers (= 4 cigarettes/day)
- History of chronic diseases that affect gastrointestinal function
- pregnant women, lactating women
- acute, active upper or lower respiratory tract infection
- Drastic, unwanted weight loss (>5% last 6 months)
- (severe) food intolerances/allergies to tomatoes, carrots, herbs, gluten, nuts
- Diabetes Mellitus Type 1 and 2
- Obesity (BMI =30 kg/m²).
- Underweight (BMI < 19 kg/m²)
- Dementia
- Self-reported severe/active liver, kidney, rheumatic diseases, and malignant tumor diseases
- hyperlipidemia
- Medications that affect fat absorption/metabolism/fat transport
- cardiac pacemakers
- Consumption of foods rich in lycopene and ß-carotene as well as zinc and selenium (tomatoes, carrots, tomato sauce, ketchup, vegetable juices, sweet potatoes, pumpkin, persimmons, apricots, papaya, mango, nectarines, peaches, pears, sea buckthorn, kale, spinach, broccoli, arugula, peas, cabbage, corn, Brazil nuts, wheat germ) each 3 days before the respective intervention day

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
bioavailability of carotenoids in young vs. old<br>time points: baseline (0h; before intervention), 90 min, 180 min, 270 min, 360 min (=end)<br>Primary outcome: Area-under-the-curve (AUC)

Secondary Outcome Measures

Name	Time	Method
Bioavailability of carotenoids in bread spread and smoothie vs. supplement capsules