Structural and Metabolic Determinants of Sarcopenia and the Efficacy of Concentric vs. Eccentric Exercise Training

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Behavioral: Concentric Exercise Training; Behavioral: Eccentric Exercise Training

• Registration Number: NCT02142855
• Lead Sponsor: University of Nottingham

Brief Summary

The first goal of this study is the follow young and older people over a period of 8 weeks to define the processes responsible for loss of muscle length and width in age-related muscle wasting (sarcopenia) and allow us to look at age-related differences in tendon. Secondly, we will assess two different exercise interventions for reversing human sarcopenia; one which involves shortening of the muscle and the other which involves lengthening, whilst also studying why these exercises work the way they do. This project will have significant implications for our understanding of the control of skeletal muscle and tendon size in humans, particularly in relation to sarcopenia and the surrounding health issues.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-05
• Study First Submitted: 2014-05-16
• Study First Submitted QC: 2014-05-19
• Study First Posted: 2014-05-20
• Primary Completion: 2017-05
• Study Completion: 2017-05
• Status Verified: 2017-10
• Last Update Submitted: 2017-10-27
• Last Update Posted: 2017-10-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 60

Inclusion Criteria

• Healthy male volunteers
• Body mass index 18-30 kg/m2
• Aged 18-35 and 65-75 years

Exclusion Criteria

• Participation in a formal exercise regime,
• A BMI < 18 or > 30 kg/m2,
• Active cardiovascular disease,
• Taking beta-adrenergic blocking agents, statins or non-steroidal anti-inflammatory drugs,
• Cerebrovascular disease,
• Respiratory disease,
• Metabolic disease,
• Active inflammatory bowel or renal disease,
• Malignancy,
• Recent steroid treatment (within 6 months) or hormone replacement therapy,
• Clotting dysfunction,
• Musculoskeletal or neurological disorders,
• Family history of early (<55y) death from cardiovascular disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Young Concentric	Concentric Exercise Training	Young individuals (18-30 y) studied before and after 8 weeks concentric exercise training
Old Eccentric	Eccentric Exercise Training	Older individuals (65-75 y) studied before and after 8 weeks eccentric exercise training
Young Eccentric	Eccentric Exercise Training	Young individuals (18-30 y) studied before and after 8 weeks eccentric exercise training
Old Concentric	Concentric Exercise Training	Older individuals (65-75 y) studied before and after 8 weeks concentric exercise training

Primary Outcome Measures

Name	Time	Method
Muscle protein synthesis	0 - 8 weeks	Comparison of muscle protein synthesis using D2O in young and older individuals and in response to 8 weeks concentric or eccentric exercise training

Secondary Outcome Measures

Name	Time	Method
Tendon protein synthesis	0 - 8 weeks	Comparison of tendon protein synthesis in young and older individuals and in response to 8 weeks concentric or eccentric exercise training

Trial Locations

Locations (1)

University of Nottingham; 🇬🇧 Derby, Derbyshire, United Kingdom