Structural and Metabolic Determinants of Sarcopenia and the Efficacy of Concentric vs. Eccentric Exercise Training: a Novel Temporospatial Approach
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Nottingham
- Enrollment
- 60
- Locations
- 2
- Primary Endpoint
- Muscle protein synthesis
Study Overview
Brief Summary
The first goal of this study is the follow young and older people over a period of 8 weeks to define the processes responsible for loss of muscle length and width in age-related muscle wasting (sarcopenia) and allow us to look at age-related differences in tendon. Secondly, we will assess two different exercise interventions for reversing human sarcopenia; one which involves shortening of the muscle and the other which involves lengthening, whilst also studying why these exercises work the way they do. This project will have significant implications for our understanding of the control of skeletal muscle and tendon size in humans, particularly in relation to sarcopenia and the surrounding health issues.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 75 Years (Adult, Older Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy male volunteers
- •Body mass index 18-30 kg/m2
- •Aged 18-35 and 65-75 years
Exclusion Criteria
- •Participation in a formal exercise regime,
- •A BMI < 18 or > 30 kg/m2,
- •Active cardiovascular disease,
- •Taking beta-adrenergic blocking agents, statins or non-steroidal anti-inflammatory drugs,
- •Cerebrovascular disease,
- •Respiratory disease,
- •Metabolic disease,
- •Active inflammatory bowel or renal disease,
- •Malignancy,
- •Recent steroid treatment (within 6 months) or hormone replacement therapy,
- •Clotting dysfunction,
- •Musculoskeletal or neurological disorders,
- •Family history of early (<55y) death from cardiovascular disease
Arms & Interventions
Old Control
Older individuals (65-75 y) with no exercise intervention
Old Concentric
Older individuals (65-75 y) studied before and after 8 weeks concentric exercise training
Intervention: Concentric Exercise Training (Behavioral)
Old Eccentric
Older individuals (65-75 y) studied before and after 8 weeks eccentric exercise training
Intervention: Eccentric Exercise Training (Behavioral)
Young Control
Young individuals (18-30 y) with no exercise intervention
Young Concentric
Young individuals (18-30 y) studied before and after 8 weeks concentric exercise training
Intervention: Concentric Exercise Training (Behavioral)
Young Eccentric
Young individuals (18-30 y) studied before and after 8 weeks eccentric exercise training
Intervention: Eccentric Exercise Training (Behavioral)
Outcomes
Primary Outcomes
Muscle protein synthesis
Time Frame: 0 - 8 weeks
Comparison of muscle protein synthesis using D2O in young and older individuals and in response to 8 weeks concentric or eccentric exercise training
Secondary Outcomes
- Tendon protein synthesis(0 - 8 weeks)