Cause and Importance of the Age-dependent Sarcopenia

Completed

• Conditions: Sarcopenia

• Registration Number: NCT02994901
• Lead Sponsor: Charite University, Berlin, Germany

Brief Summary

The goal of this cross-sectional study is to evaluate the difference in cytokine profiling approach and mitochondrial function between geriatric sarcopenic patients (group 1) and geriatric non-sarcopenic patients (group 2) and healthy (group 3) geriatric participants.

Detailed Description

Study participants (group 1\&2) are assessed during the hospital stay and age-matched controls (group 3) will be recruited through Flyers.

The investigators aim to isolate and cryopreserve peripheral blood mononuclear cells (PBMCs) from whole blood to perform functional assays on mitochondrial respiratory capacity and ROS. Furthermore, the investigators will investigate the association between biomarkers and frailty, quality of life, functional performance, fatigue and risk of depression.

The investigators hypothesize that this profiling approach will allow the evaluation of the progression of age-dependent sarcopenia and uncover novel therapeutic targets.

Study Timeline

• Study Start: 2016-11-01
• Study First Submitted: 2016-12-07
• Study First Submitted QC: 2016-12-13
• Study First Posted: 2016-12-16
• Primary Completion: 2017-06-01
• Study Completion: 2017-07-30
• Status Verified: 2020-01
• Last Update Submitted: 2020-01-27
• Last Update Posted: 2020-01-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Age between 60 and 85 years
• Informed written consent
• Normal cognitive status according to Mini-Mental State Examination (MMSE ≥ 24 points)
• Life expectancy of > 3 months according to treating doctor
• without implanted Defibrillation
• without acute Sepsis
• without neurodegenerative diseases, especially amyotrophic lateral sclerosis (ALS) and Huntington

Exclusion Criteria

• Age < 60 years or > 85 years
• Lack of informed written consent
• Low cognitive status according to Mini-Mental State Examination (MMSE < 24 points)
• Life expectancy of < 3 months according to treating doctor
• Implanted Defibrillation
• Acute Sepsis
• neurodegenerative diseases, especially amyotrophic lateral sclerosis (ALS) and Huntington

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Differences in mitochondrial respiratory capacity of peripheral blood mononuclear cells (PBMCs) using Oxygraph-2k respirometry	Baseline

Secondary Outcome Measures

Name	Time	Method
Frailty Status according to Fried et.al. criteria	Baseline
Quality of life (validated questionnaire)	Baseline
Functional limitations (single validated questionnaire)	Baseline

Trial Locations

Locations (1)

Charite University Medicine, Research Group on Geriatrics; 🇩🇪 Berlin, Germany