ACTRN12623000048684招募中未知
Effects of quinine, alone and combined with dietary nutrients, on gut function and blood glucose in healthy volunteers
Professor Christine Feinle-Bisset0 个研究点目标入组 24 人开始时间: 2023年1月16日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 发起方
- 入组人数
- 24
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 55 Years（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •-regular gastrointestinal symptoms or significant gastrointestinal disease
- •-previous gastrointestinal surgery (other than gallbladder removal)
- •-use of prescribed or non-prescribed medications (including vitamins and herbal supplements) which may affect energy metabolism, gastrointestinal function, body weight or appetite (e.g. domperidone, anticholinergic drugs (e.g. atropine), metoclopramide, erythromycin, hyoscine, orlistat, green tea extracts, Astragalus, St Johns Wort etc.)
- •-substantial daily consumption of quinine, e.g. as part of quinine-based anti-malaria treatment (irregular consumption of small amounts of quinine, e.g. in tonic water, is acceptable)
- •-regular medication that may affect any of the study outcomes (i.e. gastrointestinal motor or hormone function) and cannot be discontinued during the study
- •-using contraceptive pills, injections, IUD
- •-other food allergy
- •-current gallbladder or pancreatic disease
- •-coagulation abnormalities
- •-oesophageal varices or strictures
- •-cardiovascular or respiratory diseases that may affect any of the study outcomes and/or tolerance of the naso-duodenal tube
- •-all types of epilepsy
- •-individuals with low ferritin levels (females <15 ng/mL, males <30 ng/mL), or who have donated blood in the 12 weeks prior to taking part in the study
- •-any other illnesses as assessed by the investigator (including chronic illnesses that may affect any of the study outcomes and not explicitly listed above)
- •-high performance athletes, due to their specific dietary requirements and energy intakes (i.e. much higher than the average population), which affect gastrointestinal functions
- •-current intake of > 2 standard alcoholic drinks on > 5 days per week, due to the known effects of alcohol on gastrointestinal function
- •-current smokers/users of tobacco products (including pipe, chewing, cigarettes, cigars, sheesha, vaping)
- •-recreational drug use (e.g. marijuana)
- •-current intake of any illicit substance (since all of these, i.e. tobacco products, marijuana and illicit drugs may affect gastrointestinal functions)
- •-vegetarians
- •-inability to tolerate naso-gastric tube
- •-inability to comprehend study protocol
- •-in premenopausal females, pregnancy, lactation or surgical sterilisation (a pregnancy test will be performed, using a urine sample, on the morning of study day
- •-female participants with self-reported irregular period cycles (since studies will be performed during the follicular phase, to avoid any influences of the different stages of the menstrual cycle on study outcomes)
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