Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis

Completed

• Conditions: Acidosis, Renal Tubular; Nephrolithiasis; Vacuolar Proton-Translocating ATPases
• Interventions: Drug: Furosemide-Fludrocortisone-Test (test for urinary acidification)

• Registration Number: NCT01690039
• Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Brief Summary

Purpose

1. To compare the performance of the two currently employed urinary acidifications tests in stone formers, the furosemide/fludrocortisone and ammonium chloride loading test.

2. To study the impact of polymorphisms in the genes ATP6V1B1, ATP6V0A4 and SLC4A1 on urinary acidification in stone formers.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-09
• Study First Submitted: 2012-09-10
• Study First Submitted QC: 2012-09-17
• Study First Posted: 2012-09-21
• Primary Completion: 2016-12-31
• Study Completion: 2017-05-12
• Status Verified: 2018-10
• Last Update Submitted: 2018-10-08
• Last Update Posted: 2018-10-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 170

Inclusion Criteria

• One or more episodes of nephrolithiasis

Exclusion Criteria

• Absence of informed consent
• All conditions affecting renal acidification
• Pregnancy
• Nursing

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
All study participants	Furosemide-Fludrocortisone-Test (test for urinary acidification)	Furosemide-Fludrocortisone-Test and Ammonium chloride-Loading Test will be performed in renal stone patients.

Primary Outcome Measures

Name	Time	Method
Capability of urinary acidification	Five to six hours

Secondary Outcome Measures

Name	Time	Method
Polymorphisms in the ATP6V1 gene	12 months

Trial Locations

Locations (1)

Department of Nephrology and Hypertension, Bern University Hospital; 🇨🇭 Bern, Switzerland