Optimizing exposure therapy for Posttraumatic Stress Disorder - a single case experimental desig

• Conditions: PTSD; trauma-related symptoms; 10002861

• Registration Number: NL-OMON53620
• Lead Sponsor: niversiteit Leiden

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 16

Inclusion Criteria

In order to be eligible to participate in either study a participant must meet
all of the following criteria:
A. Diagnosed with current PTSD and satisfying DSM-5 defined criteria for
Post-Traumatic Stress Disorder as established by CAPS-5 interview (primary
diagnosis), following repeated trauma
B. Three specific memories related to the index trauma
C. Self-reported PTSD symptoms above clinical cut-off (i.e. PCL-5 score > 31;
Meer et al., 2017)
D. Three trauma-related negative cognitions with a high credibility rating
(VAS score > 70)
E. Ownership of a smart phone and being able to daily complete the digital diary
F. Age between 18 and 70 years

Exclusion Criteria

A potential participant who meets any of the following criteria will be
excluded from participation in this study:
A. Current trauma-focused treatment (e.g. prolonged exposure; EMDR)
B. Prolonged exposure treatment for PTSD in the past (>3 sessions)
C. Ongoing traumatization
D. Patients with significant suicidal ideations/serious self-injurious behavior
or who have enacted suicidal behaviors or serious self-injurious behavior
within 3 months prior to intake will be excluded from participation.
E. Autism spectrum disorder (established diagnosis by the referring institution)
F. Mental retardation (estimated IQ < 80)
G. Severe substance use disorder
H. Somatic illness that interfere with exposure interventions or planned
assessments (e.g. cardiac conditions)
I. Pregnancy
J. Participants that use psychotropic medication will not be excluded but have
to be on a stable dose for at least 6 weeks prior to enrollment.
K. Participants that cannot commit to refraining from using sedative
medication/alcohol on the days of the intervention and testing.
L. Insufficient ability to speak and write Dutch

Study & Design

• Study Type: Interventional
• Study Design: Not specified