Safest effective dose of oxytocin to avoid bleeding from uterus during cesarean section.
- Conditions
- Health Condition 1: O754- Other complications of obstetric surgery and procedures
- Registration Number
- CTRI/2019/05/019267
- Lead Sponsor
- CMS and GTBH
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other (Terminated)
- Sex
- Not specified
- Target Recruitment
- 0
All laboring parturients >18 years age who have received oxytocin for labor induction and/or augmentation, whether preeclamptics who are receiving magnesium sulfate therapy (posted for cesarean section under spinal block/general anaesthesia) or normotensives without magnesium sulfate therapy( posted for cesarean section under spinal block) will be enrolled.
Exclusion criteria will include patient refusa, history of PPH or more than one previous uterine surgery as well as bleeding disorders, and presence of abnormal placentation, uterine fibroid. Those with any contraindication to spinal block such as hemodynamic instability, infection at site of injection, coagulopathy (thrombocytopenia with platelet count <100,000/mm3) etc. will also be excluded
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The calculated ED90 of prophylactic oxytocin infusion in both cohorts.Timepoint: The status of uterine tone assessed by the operating obstetrician (satisfactory or unsatisfactory) at 4-minute post-oxytocin initiation.
- Secondary Outcome Measures
Name Time Method The requirement of additional uterotonic drugs.Timepoint: From cord clamping to end of surgery.