Treating clozapine-induced sinustachycardia (BISCLOZ).” - BISCLOZ

Aalborg Psychiatric Hospital, Centre for Skizophrenia0 个研究点目标入组 36 人开始时间: 2009年2月23日最近更新: 2021年8月2日

适应症

试验速览

暂无简介。

•Both gender
•Age 18-65 years
•Treated with clozapine for minimum 3 months and minimum 100 mg/day
•Fixed dose of antipsychotics and antidepressants during the last 14 days
•Heart rate >100
•Documentation that sinustachycardia was not present before clozapine
•Pregnancy test negative
•Sexual abstinence or birth control methods during the study and one month after
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 36
•F.1.3 Elderly (>=65 years)
•F.1.3.1 Number of subjects for this age range

•Significant substance misuse
•Physical illness which demans precautions to treatment with clozapine and bisoprolol
•Blood pressure <100/60 or dizziness causing fall
•Administration of oral anticholinergics and carbamezapine
•Treatment with betablocker 6 half-lives before inclusion or treatment with other cardiac medications (except acetylsalic acid or diuretics)
•QT alterations (QTc>500 ms) SA or AV I and II
•Retainment due to the mental health act.
•Allergic to bisoprolol or clozapine.

发起方

Aalborg Psychiatric Hospital, Centre for Skizophrenia