Patients' Outcome With Severe or Fulminant Hepatic Insufficiency, Hospitalized in the Hospitals of the Assistance Publique - Hôpitaux de Paris (APHP)
试验速览
- 阶段
- 不适用
- 入组人数
- 18,000
- 试验地点
- 1
- 主要终点
- The main objective is to determine the medical fate (transplanted or not and living or deceased), of patients with Severe and fulminating acute hepatic failure within AP-HP hospitals
研究概览
简要总结
The main objective is to determine the medical fate (transplanted or not and living or deceased), of patients with Severe, fulminating acute liver failure in the public hospitals of paris.
详细描述
Severe, fulminating acute liver failure is a rare but serious disease. The overall prognosis has improved in recent years thanks to advances in medical management and liver transplantation.
However, the epidemiology of this disease in France, the survival with or without liver transplantation of these patients and the factors that can influence this survival are not well known.
The main objective is to determine the medical fate (transplanted or not and living or deceased), of patients with Severe, fulminating acute liver failure in the public hospitals of paris (APHP).
The data will come from the APHP Health Data Warehouse
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 15 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 15
- •Severe liver failure or toxicants that may cause a liver failure Or
- •(PR<50% or INR >1.5) And ALT >250
排除标准
- •Patients with underlying chronic liver disease
- •Patients with the conditions given by this following ICD (International Classification of Diseases) : B18 - E831 - K70 - K715 - K717 - K730- K731 - K732 - 738 - K74 - K753 - K758 - K760 - K761
结局指标
主要结局
The main objective is to determine the medical fate (transplanted or not and living or deceased), of patients with Severe and fulminating acute hepatic failure within AP-HP hospitals
时间窗: 1 month from the diagnosis of this episode
Patient status 1 month after diagnosis of this episode (alive or dead with or without transplantation)
次要结局
- Epidemiology of Severe and fulminating acute hepatic failure(Baseline)
- Reasons for new hospitalizations with an admission date within 6 months after the diagnosis this episode(within 6 months after the diagnosis this episode)
- Cause of death(From date of inclusion until the date of death from any cause, assessed up to 9 years)
- Analysis of Clinical Pathway(up to 1month after the diagnosis of this episode)