Treatment of Diabetic Foot with Glutamine Dipeptide

Completed

• Conditions: Type two diabetes and diabetic foot complication; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN10878185
• Lead Sponsor: State University of Maringá

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-12-16
• Last Update Posted: 6 July 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Patients aged between 40 and 70 with type 2 diabetes and diabetic foot.

Exclusion Criteria

Severe hypertension and/or hyperlipidemia; previous history of ischemic heart disease; nephropathy, pregnancy or intention to become pregnant during the study period; changes in laboratory evaluation of aspartate amino transferase (AST), alanine amino transferase (ALT) and gamma glutamyl transferase (gamma GT).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Test sensitivity of the feet based on the National Hansen's Disease Program (NHPD) developed by the University of Baton Rouge, Louisiana / USA. <br>Interleukins, C-reactive protein, tumor necrosis factor-alpha (TNF-alfa), total antioxidant capacity, reduced protein thiols; fasting glucose, glycated hemoglobin A1c (HbA1c) and the correlation of these parameters with inflammatory markers.

Secondary Outcome Measures

Name	Time	Method
Questions on lifestyle (physical exercise, smoking and drinking), time of diagnosis, medication use, associated diseases and foot care (types of shoes, socks, presence of calluses, tingling, loss of sensation, swelling, nails and interdigital mycosis). Measurements of weight, height, waist and hip circumference will be done.