A Study Of Oral Paricalcitol To Treat Proteinuric Renal Disease
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 2
研究概览
简要总结
Diabetic Nephropathy and other proteinuric renal diseases are the major cause of kidney disease in the United States. The degree of proteinuria is associated with risk for renal disease progression and cardiovascular outcomes. Deficiency of 1-25 Vitamin D develops early in CKD, and is undertreated. Vitamin D may have important effects on factors that drive proteinuria and renal disease progression in patients with proteinuric renal diseases. Therefore, Paricalcitol treatment may reduce proteinuria and slow renal deterioration.
详细描述
Objectives:
- To determine the effect of oral paricalcitol on protein excretion in patients with proteinuric renal diseases
- To determine the effect of oral paricalcitol on renal disease progression in patients with proteinuric renal diseases Hypothesis: Oral paricalcitol will reduce protein excretion in proteinuric kidney disease Study Design: Prospective, randomized, placebo controlled, double blind, trial of paricalcitol compared to placebo.
Sample Size: 60 patients, 30 in each group Summary of Patient Eligibility Criteria: Subjects with proteinuric renal disease (>400 mg/24 hours)
Randomization and Dosage: Patients will be randomized to treatment with oral paricalcitol (initial dose 1 mcg orally per day) compared to placebo Duration : 6 Months
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Stable chronic kidney disease
- •Urine protein : Creatinine ratio > 0.4
- •Chronic kidney disease stage 2-4 with eGFR 15-90 ml/min
- •PTH (intact) >20 pg/ml and <250 pg/ml
- •If on ACEI/ARB, then dose optimized (BP, K)
排除标准
- •Failure to provide informed consent
- •Glomerunephritis requiring active treatment with immunosuppresive therapy
- •Serum phosphorus > 5.2
- •Serum calcium (adjusted for albumin)> 10.0
- •Active malignancy
- •Likelihood of requiring renal replacement therapy within 1 year
- •Uncontrolled hypertension