General practice study about chest infections in adults

Not Applicable

• Conditions: Vaccine-preventable acute lower respiratory tract infections; Respiratory; Unspecified acute lower respiratory infection

• Registration Number: ISRCTN64997989
• Lead Sponsor: niversity of Bristol

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-04-04
• Last Update Posted: 15 April 2024
• Study Completion: 2024-12-28

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 2700

Inclusion Criteria

1. Aged =18 years of age; AND
2. Presenting to primary care with acute illness (i.e., present for 28 days or less); AND
3. Evidence of aLRTD* as guided by the following criteria:
3.1. Evidence of aLRTI (including acute bronchitis, pneumonia and infective exacerbations of chronic lung disease):
3.1.1. Clinical suspicion of LRTI and new/worsened cough with one or more of the following signs/symptoms: sputum production or purulence, chest pain, wheeze, shortness of breath, tachypnoea or abnormal auscultatory findings suggestive of aLRTI; OR
3.1.2. Clinical diagnosis of aLRTI OR
3.2. Evidence of acute exacerbation of pre-existing heart failure with respiratory symptoms:
3.2.1. Clinical suspicion of acute exacerbation of pre-existing heart failure and new or worsening of two or more of the following signs/symptoms: cough (including nocturnal cough), shortness of breath, wheeze, tachypnoea, abnormal auscultatory findings suggestive of exacerbation of heart failure; OR
3.2.2. Clinical diagnosis of acute exacerbation of heart failure with respiratory symptoms OR
3.3. Evidence of non-infective exacerbation of pre-existing chronic lung disease:
3.3.1. Clinical suspicion of presumed non-infective exacerbation of pre-existing chronic lung disease and new or worsening of two or more of cough, shortness of breath, wheeze, tachypnea, abnormal auscultatory findings suggestive of acute non-infective exacerbation; OR
3.3.2. Clinical diagnosis of non-infective exacerbation

*Acute lower respiratory tract disease (aLRTD) includes acute lower respiratory tract infection (aLRTI) and its subgroups, acute exacerbation of pre-existing heart failure and presumed non-infective exacerbation of chronic lung disease.

Exclusion Criteria

1. Previously enrolled participants within 28 days of the onset of the study qualifying aLRTD illness
2. At the time of enrolment, alternative non-LRTD working diagnosis suspected
3. Presenting to primary care with the same episode of aLRTD for which they have been discharged from hospital
4. Any patient who develops signs and symptoms of LRTD after being hospitalized for =48 hours

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The incidence of acute lower respiratory tract infection (aLRTI) in adults presenting to primary care and the proportion caused by vaccine preventable infections, including Streptococcus pneumoniae, Respiratory Syncytial Virus (RSV) and SARS-CoV-2. Measured using data extracted from primary care medical records and samples collected over a 30-month period between February 2022 and July 2024.