ACTRN12616001265460已完成未知
A Phase II study of local therapy only (stereotactic radiosurgery and/or surgery) for treatment of up to 5 brain metastases from HER2 positive Breast Cancer
Trans Tasman Radiation Oncology Research Group (TROG)0 个研究点目标入组 25 人开始时间: 2016年9月8日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 25
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomised trial
- 主要目的
- Treatment
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •18 years or older
- •- metastatic HER2 positive breast cancer
- •- 1-5 synchonous brain metastases (At least 1 lesion must require treatment with surgery or SRS, Maximum volume of any single PTV <10cm3 and Summated volume of all lesions to be treated with SRS is < 15cm3. If a lesion is too small for treatment and will be observed, then its volume is not included in this summation).
- •- ECOG 0-2
- •- Absent or stable extracranial disease or active extracranial disease that is likely to be controlled with further HER-2 targeted therapy.
- •- Receiving systemic HER2 targeted therapy, or planned to receive within 4 weeks of completion of brain metastasis treatment
- •- Able to undergo MRI scanning
排除标准
- •- Previous treatment to the target brain metastases (excluding surgery within 6 weeks of registration)
- •- Previous whole brain radiotherapy (WBRT)
- •- Any brain metastasis that is greater than 40mm in size and unable to be resected
- •- Leptomeningeal disease
- •- Pregnant or breastfeeding
研究者
相似试验
招募中
2 期
Preceding local therapy to STRIDE for pretreated patientsHepatocellular carcinomaJPRN-jRCT1041230013Yamashita Tatsuya36
Unknown
2 期
Chemo- radiotherapy of cancer of cheek with Tomotherapy .CTRI/2010/091/002920Tata Memorial Hospital55
已完成
不适用
A study of potentially curative local therapy alone, or preceded by chemotherapy, in the treatment of Stage Ib-IVa cervical carcinomaCervical cancerCancerISRCTN79554459Medical Research Council (MRC) (UK)313
已完成
不适用
Single-arm phase II study of aggressive local therapy in combination with systemic chemotherapy for stageIV non-small cell carcinoma not harboring EGFR mutation and ALK fusion gene with oligometastasesJPRN-UMIN000022431Thoracic Oncology Research Group19
招募中
2 期
Radiation treatment prior to surgery for local spine metastasisACTRN12615001031550Epworth HealthCare20