Patient Profiling for Successful Weight Loss After Gastric Bypass or Sleeve Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 55
- 试验地点
- 2
- 主要终点
- Weight loss
研究概览
简要总结
The overall aim is to study the multiple factors determining the variation of weight loss after Roux-en-Y Gastric Bypass (RYGB) and Sleeve surgery.
The specific aims are to evaluate:
a) what explains the large individual differences in weight loss seen after RYGB and Sleeve surgery, b) if it is possible pre-operatively to identify which patients will not obtain beneficial effects of bariatric surgery in relation to weight loss and quality of life and c) if patients in need of improved care can be identified pre- and/or early post-operatively.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients approved for bariatric surgery at Bariatric Clinic, Køge Hospital, Denmark
排除标准
- •Inability to comply with the study protocol
研究组 & 干预措施
Surgery
干预措施: Roux-en-Y gastric bypass surgery or sleeve surgery (Procedure)
结局指标
主要结局
Weight loss
时间窗: 3 month preoperatively, 1 week preoperatively, 6 weeks postoperatively, 6 month postoperatively and 18 month postoperatively
次要结局
- Social resources(3 month preoperatively, 1 week preoperatively, 6 weeks postoperatively, 6 month postoperatively and 18 month postoperatively)
- Bile acids and fibroblast growth factors(3 month preoperatively, 1 week preoperatively, 6 month postoperatively and 18 month postoperatively)
- Taste preferences and taste perception(3 month preoperatively, 1 week preoperatively, 6 weeks postoperatively, 6 month postoperatively and 18 month postoperatively)
- Genetics(3 month preoperatively)
- Gut microbiota(1 week preoperatively, 6 month postoperatively)
- Appetite-regulating hormones(3 month preoperatively, 1 week preoperatively, 6 month postoperatively and 18 month postoperatively)
- Physical activity(3 month preoperatively, 1 week preoperatively, 6 month postoperatively and 18 month postoperatively)
- Mental health(3 month preoperatively, 6 month postoperatively and 18 month postoperatively)
- Body composition(3 month preoperatively, 1 week preoperatively, 6 weeks postoperatively, 6 month postoperatively and 18 month postoperatively)
- Metabolic profile(3 month preoperatively, 1 week preoperatively, 6 month postoperatively and 18 month postoperatively)
- Appetite sensation(3 month preoperatively, 1 week preoperatively, 6 weeks postoperatively, 6 month postoperatively and 18 month postoperatively)
- Cortisol(3 month preoperatively and 18 month postoperatively)
- Rewarding value of food(preoperatively and 6 month postoperatively)
- Neural activity in reward-processing brain centers(preoperatively and 6 month postoperatively)
研究者
Arne Astrup
Prof., MD, Head of Department of Nutrition, Exercise and Sports
University of Copenhagen