Prenatal and Childhood Nutrient Mixtures Predict Neurodevelopmental Outcomes Among Children in Mexico City
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 329
- 试验地点
- 1
- 主要终点
- McCarthy Scales of Children's Abilities (MSCA)
研究概览
简要总结
Background: Adequate levels of beneficial nutrients are important for neurodevelopment. Although, nutrients are ingested in combination, considering nutrients as a mixture has not been studied with respect to health, such as neurodevelopment.
Objective: To examine the impact of prenatal and childhood nutrition mixtures on neurodevelopment.
Design: Participants included mother-child pairs in the Programming Research in Obesity, Growth Environment and Social Stress (PROGRESS) prospective birth cohort in Mexico City. Prenatal and child nutrition profiles were assessed among 65 and 329 children respectively by analyzing components of a food frequency questionnaire. Child neurodevelopmental outcomes at 4-6 years of age were measured using the McCarthy Scales of Children's Abilities (MSCA).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 44 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Women of children:
- •less than 20 weeks gestation at the start of the study
- •at least 18 years of age
- •and planned to reside in Mexico City for the next three years.
排除标准
- •Women of children:
- •free of heart or kidney disease
- •not use steroids or anti-epilepsy drugs
- •not consume alcohol.
结局指标
主要结局
McCarthy Scales of Children's Abilities (MSCA)
时间窗: at age 4
The MSCA consists of 18 short sub-tests that are weighted and combined to yield five scale scores or indexes - verbal, perceptual performance, quantitative, memory and motor - as well as an overall general cognitive index based on the first three scaled indexes. The McCarthy Scale index scores can range from 22 - 78 with higher index scores indicating better outcome.
次要结局
未报告次要终点