Remote Ischemic Preconditioning of Dynamic Cerebral Autoregulation in Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- phase difference(PD) in degree
研究概览
简要总结
The purpose of this study is to determine the impact of remote ischemic preconditioning on dynamic cerebral autoregulation and related hematology indexes in healthy adults.
详细描述
Remote ischemic preconditioning(RIPC) is the phenomenon whereby brief cycles of ischemia and reperfusion, applied to a distant organ, provide protection to the target organ. Dynamic cerebral autoregulation(dCA), a mechanism to maintain the cerebral blood flow, has been proved to be critical for the occurrence,development and prognosis of ischemic neurovascular disease. In this study, we hypothesis that RIPC provides neuro-protection by means of improving dCA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age from 18 to 70,both genders
- •Willing to participate in follow-up visits
排除标准
- •current or having a history of chronic physical diseases or mental diseases
- •suffering from infectious diseases in late one month
- •pregnant and lactating women；
- •smoking or drinking；
- •inability to cooperate sufficiently to complete the dCA examination
研究组 & 干预措施
RIPC Group
RIPC was induced by 4 cycles of extremities ischemia (5-minute blood-pressure cuff inflation to 200 mm Hg, followed by 5-minute cuff deflation).All subjects will take RIPC intervention, blood collection and 7 dCA measurements.
干预措施: Remote ischemic conditioning equipment (Device)
RIPC Group
RIPC was induced by 4 cycles of extremities ischemia (5-minute blood-pressure cuff inflation to 200 mm Hg, followed by 5-minute cuff deflation).All subjects will take RIPC intervention, blood collection and 7 dCA measurements.
干预措施: Intravenous blood collection (Procedure)
RIPC Group
RIPC was induced by 4 cycles of extremities ischemia (5-minute blood-pressure cuff inflation to 200 mm Hg, followed by 5-minute cuff deflation).All subjects will take RIPC intervention, blood collection and 7 dCA measurements.
干预措施: dCA measurement (Procedure)
结局指标
主要结局
phase difference(PD) in degree
时间窗: 2 days
A dynamic cerebral auto-regulation parameter derived from transfer function analysis.Continuous cerebral blood flow velocities of bilateral middle cerebral artery will be assessed noninvasively using transcranial Doppler. Spontaneous arterial blood pressure will be simultaneously recorded using a servo-controlled plethysmograph on the left or right middle finger with an appropriate finger cuff size. Transfer function analysis will be used to derive the autoregulatory parameters.
the rate of recovery of cerebral blood flow velocity
时间窗: 2 days
gain in cm/s/mmHg
时间窗: 2 days
次要结局
- pulsatility index (PI) changes from supine to upright position(2 days)
- resistance index (RI) changes from supine to upright position(2 days)
- mean middle cerebral artery blood flow velocity (mCBFV) changes from supine to upright position(2 days)
研究者
Yi Yang
Associated Dean of First Hospital of Jilin University
The First Hospital of Jilin University