Association Between CytochromeP4501A2 and CytochromeP4502E1 Gene Polymorphisms and Metabolism of Theophylline

Not Applicable

Completed

• Conditions: Chronic Obstructive Pulmonary Disease
• Interventions: Drug: theophylline

• Registration Number: NCT02001935
• Lead Sponsor: Zhujiang Hospital

Brief Summary

The aim of this study is to determine whether common CYP1A2 and CYP2E1 gene polymorphisms effect metabolism of theophylline in chronic obstructive pulmonary disease patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-09
• Study First Submitted: 2013-11-12
• Study First Submitted QC: 2013-11-28
• Study First Posted: 2013-12-05
• Status Verified: 2014-07
• Primary Completion: 2014-07
• Study Completion: 2014-07
• Last Update Submitted: 2014-08-19
• Last Update Posted: 2014-08-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

• Aged 18-75 years,COPD patients, male or female;
• regularly visiting our hospital;
• taking a sustained-release preparation of theophylline continuously for at least 2 weeks

Exclusion Criteria

• patients with renal or hepatic dysfunction;
• patients with congestive heart failure;
• patients with hypothyroidism or hyperthyroidism;
• patients currently taking drugs likely to affect theophylline metabolism or who had taken such drugs in the preceding week;
• patients with extreme obesity
• patients with very severe Chronic Obstructive Pulmonary Disease(COPD)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
theophylline	theophylline	-

Primary Outcome Measures

Name	Time	Method
Theophylline clearance	Blood samples will be taken after receiving oral thoephylline for 14 days	Theophylline and it's metabolite(1,3-dimethyluric) blood concentration

Trial Locations

Locations (1)

Zhujiang Hospital,Southern Medical Universtiy; 🇨🇳 Guangzhou, Guangdong, China