Evaluation of change in neurocognition with midazolam sedation in regional anesthesia
Not Applicable
- Conditions
- Health Condition 1: M959- Acquired deformity of musculoskeletal system, unspecified
- Registration Number
- CTRI/2021/02/031194
- Lead Sponsor
- Department of anesthesia
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Age > 40 years.
2.American Society of Anaesthesiologists (ASA) class I and II.
3.Duration of surgery > 1hour
4.Patients undergoing lower limb orthopaedic surgery under regional anaesthesia.
Exclusion Criteria
1.Preoperative cognitive dysfunction [mini- cog score <3 and state trait anxiety score
>42].
2.Patients with known psychiatric illness or on antipsychotic drugs or substance
abuse.
• Severe hepatic or renal insufficiency
• Level of education less than 5 th class schooling.
• Any carotid or cerebrovascular disease or brain pathology.
• Contraindications to regional anaesthesia
• Allergy to any of drug used in the procedure
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To detect the incidence of early neurocognitive function with the use of midazolam as <br/ ><br>sedative in patients undergoing lower limb orthopaedic surgery under regional anaesthesiaTimepoint: 3 rd and 7 th pod
- Secondary Outcome Measures
Name Time Method Determination of factors associated with neurocognitive change. <br/ ><br>Timepoint: 3rd and 7 th pod