Intervention to Improve HIV Care Retention and Antiretroviral Adherence in Stigmatized Environments
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- HIV I Infection
- Sponsor
- University of Connecticut
- Enrollment
- 3771
- Locations
- 2
- Primary Endpoint
- Medical Records of Care Appointments
- Status
- Active, not recruiting
- Last Updated
- 8 months ago
Overview
Brief Summary
Retention in care and persistent adherence to antiretroviral therapy are necessary for the successful treatment of HIV infection. HIV-related stigma is a known impediment to the care and health outcomes of people living with HIV. The proposed study will test theory-based interventions designed to manage HIV stigma in order to improve care retention and medication adherence in communities with high-levels of HIV-related stigma.
Detailed Description
This trial is conducting a randomized test of a behavioral self-management intervention designed to improve HIV treatment outcomes in people living with HIV in stigmatized contexts. The trial includes a control arm and a non-stigma enhanced treatment adherence intervention arm. Participants living in an economically under-resourced area of South Africa are recruited through clinical care settings. The goal of the research is to examine whether directly addressing HIV stigma and medication adherence management improves treatment outcomes beyond those observed from a standard behavioral intervention without added stigma-addressing components.
Investigators
Eligibility Criteria
Inclusion Criteria
- •18 years of age or older
- •current clinic visit to receive cART in differentiated care outside of an adherence club
- •unsuppressed HIV at the most recent clinical testing confirmed in run-in
- •access to a phone
Exclusion Criteria
- •Not meeting inclusion
Outcomes
Primary Outcomes
Medical Records of Care Appointments
Time Frame: 12-months
Medical records are retrospectively collected for all scheduled care visits and coded for whether the visits were attended.The records are exclusively from the clinic where patients are initially recruited and with patient permission. The data obtained are expressed as the ratio of the number of care appointments attended relative to the number scheduled.
Blood Plasma RNA
Time Frame: 12-months
Collection of dried blood spots are tested for HIV RNA (viral load) using PCR tests with results expressed as the number of RNA copies per mL of blood plasma.
Secondary Outcomes
- Antiretroviral Medication Adherence(12-months)