A Comparative Evaluation of the Regenerative Potential of alloplastic material Beta-Tricalcium Phosphate (β-TCP) and Autologous Platelet Rich Fibrin (PRF) in the treatment of Mandibular Furcation Defects: A Clinico-Radiographic Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 31
- 试验地点
- 1
- 主要终点
- horizontal clinical attachment level (HCAL), gingival recession (GR), relative vertical height of furcation (r-VHF) and relative horizontal depth of furcation (r-HDF)] and radiogaraphic parameters [horizontal depth of furcation (H-DOF), vertical height of furcation (V-HOF)]
研究概览
简要总结
Objective: The objective of the study was to evaluate clinically and radiographically the efficacy of platelet ’rich fibrin (PRF) versus β ’tri calcium phosphate (β ’TCP) in the treatment of Grade II mandibular furcation defects. Materials and Methods: Forty ’five Grade II furcation defect in mandibular molars which were assigned to open flap debridement (OFD) with PRF Group I (n = 15), to OFD with β TCP Group II (n = 15), and to OFD alone Group III (n = 15) were analyzed for clinical parameters (probing pocket depth [PPD], vertical in 31 patients clinical attachment level [VCAL], horizontal clinical attachment level [HCAL], gingival recession, relative vertical height of furcation [r ’VHF], and relative horizontal depth of furcation [r ’HDF]) and radiographical parameters (horizontal depth of furcation [H ’DOF], vertical height of furcation [V ’HOF]) using cone ’beam computed tomography (CBCT) at 6 months interval. Results: For clinical parameters, reduction in PPD and gain in VCAL and HCAL were higher in Group II as compared to Group I. Change in r ’VHF and r ’HDF was greater in Group II as compared to Group I. Mean percentage clinical vertical defect fill was higher in Group II as compared to Group I (58.52% ± 11.68% vs. 53.24% ± 13.22%, respectively). On CBCT, mean change at 6 months for all parameters showed nonsignificant difference between the two experimental groups. Mean change in V ’HOF was higher in Group I as compared to Group II, but mean change in H DOF and furcation width was more in Group II as compared to Group I. Conclusion: For both experimental and control groups, there was statistically significant improvement at 6 months follow ’up from baseline values.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Outcome Assessor Blinded
入排标准
- 年龄范围
- 30.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •Systemically healthy patients within the age group 30-50 years suffering from moderate to severe generalized chronic periodontitis.
- •Patient having at least one Glickman’s buccal grade II furcation defects in mandibular 1st and 2nd molars with ≥3mm horizontal probing depth.
- •Involved tooth must have gingival margin coronal to or at the level of the roof of furcation (fornix).
- •Patients who had not taken antibiotics or any other drug within 6 months that may modify the result of periodontal therapy.
- •Non mobile tooth.
- •Adequate RCT must have been completed 3 months before the commencement of the study.76 7) Compliant patient with full mouth plaque score 0.1 to 0.9 (good oral hygiene during phase I therapy).
排除标准
- •Smokers and tobacco chewers 2) Pregnant and lactating mothers 3) Individual allergic to medication 4) History of periodontal surgery within 6 months 5) Inadequate endodontic treatment and/or restoration, with trauma from occlusion (TFO) or occlusal disharmony.
- •Lingual Class II furcation defects.
结局指标
主要结局
horizontal clinical attachment level (HCAL), gingival recession (GR), relative vertical height of furcation (r-VHF) and relative horizontal depth of furcation (r-HDF)] and radiogaraphic parameters [horizontal depth of furcation (H-DOF), vertical height of furcation (V-HOF)]
时间窗: Horizontal clinical attachment level (HCAL), gingival recession (GR), relative vertical height of furcation (r-VHF) and relative horizontal depth of furcation (r-HDF)] and radiogaraphic parameters [horizontal depth of furcation (H-DOF), vertical height of furcation (V-HOF)] at 6 months
次要结局
- Clinical parameters [probing pocket depth (PPD), vertical clinical attachment level (VCAL), Radiographic analysis, Data are compared at asilene and 6 Months on CBCT(Data are compared at asilene and 6 Months on CBCT)