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Collection of Blood in Studying Metabolites in Patients With Prostate Cancer

Recruiting
Conditions
Prostate Carcinoma
Interventions
Procedure: Biospecimen Collection
Other: Laboratory Biomarker Analysis
Registration Number
NCT03485794
Lead Sponsor
University of Southern California
Brief Summary

This pilot research trial utilizes the collection of blood in studying metabolites in patients with prostate cancer. Metabolites are the small molecule products of cellular metabolism that are produced naturally in all living cells. Collecting blood in order to study metabolites may help doctors monitor and treat prostate cancer more effectively.

Detailed Description

PRIMARY OBJECTIVES:

I. Develop blood sample collection and preparation procedures for reliable, meaningful metabolomic profiling of peripheral blood mononuclear cells (PBMCs) by liquid chromatography/quadruple-time of flight/mass spectrometry (LC/Q-TOF/MS) that can be implemented in a clinical setting.

II. Optimize data analysis methods and software usage to create a metabolic profile for patients at the time of blood collection.

III. Compare metabolite profiles of isolated PBMCs versus (vs.) other blood fractions (plasma, red blood cells \[RBCs\], and whole blood).

IV. Identify elements of the PBMC metabolite profile that may correlate to patient disease state.

OUTLINE:

Patients undergo collection of blood for metabolic profiling via LC/Q-TOF/MS.

Recruitment & Eligibility

Status
RECRUITING
Sex
Male
Target Recruitment
10
Inclusion Criteria
  • All subjects will have histologically confirmed prostate cancer
  • Provide written consent/authorization to participate in this study
  • Have no signs or symptoms of active infection
  • Exhibit a willingness to comply with the experimental procedures as outlined in this protocol
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Exclusion Criteria

Not provided

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Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Arm && Interventions
GroupInterventionDescription
Diagnostic (biospecimen collection)Biospecimen CollectionPatients undergo collection of blood for metabolic profiling via LC/Q-TOF/MS.
Diagnostic (biospecimen collection)Laboratory Biomarker AnalysisPatients undergo collection of blood for metabolic profiling via LC/Q-TOF/MS.
Primary Outcome Measures
NameTimeMethod
Blood sample collectionBaseline

The blood will be used to analyze the metabolites produced by white blood cells.

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

USC / Norris Comprehensive Cancer Center

🇺🇸

Los Angeles, California, United States

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