Collection of Blood in Studying Metabolites in Patients With Prostate Cancer
- Conditions
- Prostate Carcinoma
- Interventions
- Procedure: Biospecimen CollectionOther: Laboratory Biomarker Analysis
- Registration Number
- NCT03485794
- Lead Sponsor
- University of Southern California
- Brief Summary
This pilot research trial utilizes the collection of blood in studying metabolites in patients with prostate cancer. Metabolites are the small molecule products of cellular metabolism that are produced naturally in all living cells. Collecting blood in order to study metabolites may help doctors monitor and treat prostate cancer more effectively.
- Detailed Description
PRIMARY OBJECTIVES:
I. Develop blood sample collection and preparation procedures for reliable, meaningful metabolomic profiling of peripheral blood mononuclear cells (PBMCs) by liquid chromatography/quadruple-time of flight/mass spectrometry (LC/Q-TOF/MS) that can be implemented in a clinical setting.
II. Optimize data analysis methods and software usage to create a metabolic profile for patients at the time of blood collection.
III. Compare metabolite profiles of isolated PBMCs versus (vs.) other blood fractions (plasma, red blood cells \[RBCs\], and whole blood).
IV. Identify elements of the PBMC metabolite profile that may correlate to patient disease state.
OUTLINE:
Patients undergo collection of blood for metabolic profiling via LC/Q-TOF/MS.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Male
- Target Recruitment
- 10
- All subjects will have histologically confirmed prostate cancer
- Provide written consent/authorization to participate in this study
- Have no signs or symptoms of active infection
- Exhibit a willingness to comply with the experimental procedures as outlined in this protocol
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Diagnostic (biospecimen collection) Biospecimen Collection Patients undergo collection of blood for metabolic profiling via LC/Q-TOF/MS. Diagnostic (biospecimen collection) Laboratory Biomarker Analysis Patients undergo collection of blood for metabolic profiling via LC/Q-TOF/MS.
- Primary Outcome Measures
Name Time Method Blood sample collection Baseline The blood will be used to analyze the metabolites produced by white blood cells.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
USC / Norris Comprehensive Cancer Center
🇺🇸Los Angeles, California, United States