Effects of Continous Positive Airway Pressure (CPAP) in Hypertrophic Cardiomyopathy

Not Applicable

Completed

• Conditions: Non-obstructive Hypertrophic Cardiomyopathy; Obstructive Hypertrophic Cardiomyopathy
• Interventions: Device: CPAP

• Registration Number: NCT01631006
• Lead Sponsor: University of Sao Paulo

Brief Summary

Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiac disease, is a cause of disability including heart failure, atrial fibrillation, and sudden death, with an annual mortality varying from 1% to 6%. Obstructive sleep apnea (OSA) is extremely common among patients with established cardiovascular disease, including hypertension and atrial fibrillation and when present may contribute to worse cardiovascular outcome. Although patients with HCM do not necessarily have typical characteristics of patients with OSA, such as obesity and increasing age, there is recent evidence that OSA is extremely common among patients with HCM, with a prevalence ranging from 32% to 71%. The presence of OSA among patients with HCM is independently associated with worse structural and functional impairment of the heart, including atrial and aorta enlargement, worse New York Heart Association functional class, and worse quality of life. Therefore, the recognition and treatment of OSA is a new area of research that may impact in the management of patients with HCM.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2012-01
• Study First Submitted: 2012-06-26
• Study First Submitted QC: 2012-06-27
• Study First Posted: 2012-06-28
• Primary Completion: 2012-12
• Study Completion: 2013-04
• Status Verified: 2014-12
• Last Update Submitted: 2014-12-18
• Last Update Posted: 2014-12-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

• both genders
• over 18 years-old
• hemodynamically stable
• with no other cardiac disease
• consent form signed

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Exclusion Criteria

• presence of pacemaker
• spontaneous withdrawal
• previous cardiorespiratory arrest
• atrial fibrilation during echocardiography

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Low CPAP pressure	CPAP	Patients are submmited to a CPAP with low pressure for 20 minutes
High CPAP pressure	CPAP	Patients are submmited to a high pressure of CPAP for 20 minutes

Primary Outcome Measures

Name	Time	Method
Cadiac performance by echocardiography	acutely

Trial Locations

Locations (1)

Heart Institute; 🇧🇷 Sao Paulo, Brazil