Fat-Associated Cardiovascular Organ Dysfunction
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Overweight
- Sponsor
- Haukeland University Hospital
- Enrollment
- 618
- Locations
- 1
- Primary Endpoint
- Dilated left atrium
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
This is an observational study of cardiovascular risk factors and arterial or cardiac function in subjects with overweight or obesity. Subjects must be between 30 and 65 years of age, have a body mass index >27.0 kg/m2 and free from known heart disease and digestive or psychiatric disorders. Study aims include identifying sex-differences in traditional cardiovascular risk factors and structural and functional abnormalities in arteries and the heart in subjects with overweight or obesity, and how this is influenced by physical fitness.
Detailed Description
FATCOR is an observational study of women and men with overweight or obesity. In particular prevalences of conventional cardiovascular risk factors and subclinical arterial or cardiac dysfunction are explored. The study aims at identifying sex differences in presence and clustering of cardiovascular risk factors and presence of subclinical cardiovascular organ damage. The influence of physical fitness on these factors will also be assessed. All participants undergo extensive cardiovascular risk factor assessment including oral glucose tolerance test and ambulatory blood pressure recording. Subclinical cardiovascular dysfunction is assessed by carotid and femoral vascular ultrasound, echocardiography and carotid-femoral pulse wave velocity using applanation tonometry. Physical fitness is assessed from peak oxygen uptake during maximal exercise testing on a treadmill.
Investigators
Eligibility Criteria
Inclusion Criteria
- •body mass index \> 27.0 kg/m2
Exclusion Criteria
- •known heart disease
- •digestive disorder
- •psychiatric disorder
- •unfamiliar with Norwegian language
Outcomes
Primary Outcomes
Dilated left atrium
Time Frame: At study baseline
Echocardiography
Abnormal left ventricular geometry
Time Frame: At study baseline
Echocardiography
Secondary Outcomes
- Relation of physical fitness to prevalence of cardiovascular risk factors(At study baseline)
- Relation of sex to arterial stiffness(At study baseline)
- Relation of sex to prevalence of hypertension(At study baseline)
- Relation of sex to abnormal left ventricular geometry(At study baseline)