Anthropometric, Metabolic, Cardiovascular and Symptomatic Profile in Postmenopausal Women

Completed

• Conditions: Postmenopausal Disorder
• Interventions: Other: Clinical exams

• Registration Number: NCT01745042
• Lead Sponsor: University of Sao Paulo

Brief Summary

The purpose of this study is to investigate anthropometric, metabolic, cardiovascular and symptomatic profiles in postmenopausal women.

Detailed Description

When aging, the body composition changes, leading to a reduction of muscle mass and strength, and to an increase in total body fat. These body composition changes have especially been observed in postmenopausal women, due to the hormonal changes taking place. After the menopause, the gynoid fat distribution with fat deposits in the gluteo-femoral region changes to an android fat distribution with an increased upper body fat, especially in the abdominal region. These consequences of the menopause associated with a decrease in aerobic capacity and reduced total energy expenditure may lead to the metabolic syndrome (MetS). The aim of this study was to investigate the anthropometric, metabolic, cardiovascular and symptomatic profile in gynoid and android postmenopausal women.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2009-09
• Primary Completion: 2009-12
• Study Completion: 2009-12
• Status Verified: 2012-12
• Study First Submitted: 2012-12-03
• Study First Submitted QC: 2012-12-05
• Last Update Submitted: 2012-12-05
• Study First Posted: 2012-12-07
• Last Update Posted: 2012-12-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 45

Inclusion Criteria

• Postmenopausal women
• Caucasian
• 50-60 years of age

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Exclusion Criteria

• Neurological disease
• Pulmonary disease
• Cardiac disease
• Oncological disease
• Musculotendinous or articular injuries
• Hormone replacement therapy
• Cigarette smoking

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
gynoid postmenopausal women	Clinical exams	Clinical exams
android postmenopausal women	Clinical exams	Clinical exams

Primary Outcome Measures

Name	Time	Method
Relationships between postmenopause and fat distribution	Baseline	Anthropometric measurements: waist-to-hip ratio and body mass index

Secondary Outcome Measures

Name	Time	Method
Comparison of the body composition between android and gynoid postmenopausal women	Baseline	Body composition: bipolar electrical bioimpedance (body fat and lean mass) and skinfolds (triceps, subscapular, suprailiac, abdominal, anterior thigh, medial calf)
Comparison of metabolic parameters between android and gynoid postmenopausal women	Baseline	Biochemical tests: the serum level of estradiol, urea, creatinine, triglycerides, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein (VLDL) cholesterol, insulin and glucose
Comparison of quality of life between android and gynoid postmenopausal women	Baseline	Menopause Rating Scale (MRS): somatic symptoms; psychological symptoms; urogenital-sexual problems
Comparison of aerobic capacity between android and gynoid postmenopausal women	Baseline	Progressive aerobic testing on treadmill (Modified Bruce Protocol): estimated maximum oxygen consumption; metabolic equivalents; blood pressure; heart rate

Trial Locations

Locations (1)

Optics Group from Physics Institute of São Carlos (IFSC), University of São Paulo (USP); 🇧🇷 São Carlos, São Paulo, Brazil