Study of seasonal Haritaki use in Dyslipidemia in winter season

Phase 3

Not yet recruiting

• Conditions: Hyperlipidemia, unspecified. Ayurveda Condition: MEDOROGAH,

• Registration Number: CTRI/2022/12/047928
• Lead Sponsor: PDEAS College of Ayurved and Research centre

Brief Summary

Elevated plasmacholesterol levels are a major risk factor for cardiovascular diseases.Atherosclerotic plaque formation is an inflammatory process in the endothelialvessel wall associated with retained low-density lipoprotein (LDL). Strategiesto combat elevated cholesterol levels include lifestyle changes andpharmacological interventions.

Drug treatment of high blood lipids isnecessary to reduce cardiovascular risk and prevent heart attacks, strokes,high blood pressure, fatty liver disease, diabetes, among people with thiscondition. To prevent & cure these diseases Rutu Haritaki can act effectivelyas Rasayan by balancing vitiation of dosha. Haritaki is advocated for allseasons along with specific Anupan in Bhavprakash Samhita to balancephysiological variations of dosha due to seasonal changes.In shishir rutu saccumulation of Kapha dosha takes place.

Acharya Bhavamishra stated that Haritaki shouldbe taken with the adjuvant Pippali in Shishir Rutu. Pippali  pacifieskaphadosha. Haritiki & Pippali both pacifies kapha Vata dosha. ThusHaritaki along with Pippali in Shishir Rutu maintains equilibrium of tridosha.Excessive accumulation of kapha dosha can lead to increase in Medadhatu. Currently available hypolipidemic drugs have been associated with anumber of side effects.Properties of Haritaki as mentioned in samhita is havingpredominance of Kashaya Rasa & Ushnaveerya. Due to these properties itcauses reduction in Medodushti. Hence Haritaki can be used to reducedyslipidemia. Hence this study is selected.

Patient with abnormal lipid profile and agedbetween 40 to 60 years will be selected. Study drug & control Drug will beprovided to the patient in two groups for 60 days. Assessment will be done bysubjective & objective parameters. Analysis will be done. Conclusion willbe drawn.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2022-06-12
• Study Start: 2022-09-12

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

• Patients in age group 40 to 60 years, either male or female, irrespective of occupation & Patients who are not taking any medication for management of Dyslipidemia.
• Patients having alterations in lipid profile as follows will be selected.

Exclusion Criteria

• Individuals suffering from any severe systemic illness, serious acute &chronic illness Patients with history of cardiovascular disease, Previous history of stroke, will be excluded.
• Patients suffering from type 1 DM, Uncontrolled Type 2 DM, Type 2 DM patients taking insulin, diastolic Blood pressure >90 mm of Hg, Patients having history of Chronic liver & kidney Disease, Malignancy, Patients on medication with corticosteroids, diuretics will be excluded.
• Pregnant & Lactating women Patients suffering from Pitta aggravation symptoms.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improvement in levels of Cholesterol in patients of dyslipidemia	0 days,8 weeks

Secondary Outcome Measures

Name	Time	Method
BMI	0 days,8 weeks

Trial Locations

Locations (1)

Ayurved Rugnalaya & Sterling Multispeciality Hospital; 🇮🇳 Pune, MAHARASHTRA, India

Ayurved Rugnalaya & Sterling Multispeciality Hospital

🇮🇳Pune, MAHARASHTRA, India

DrManore DJ

Principal investigator

9881650526

dr.manore@gmail.com