Epigenetic Changes in Psychotherapy of Adolescents With Borderline Personality Pathology
- Conditions
- Borderline Personality Disorder (BPD)
- Registration Number
- NCT04095546
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Brief Summary
The link between epigenetic changes as an effect of psychotherapy has been investigated recently. Genes investigated in these studies were brain-derived neurotrophic factor (BDNF), NR3C1, FKBP51, MAOA and GLUT1. Change in methylation of these genes could be a biomolecular mechanism of psychotherapy induced changes. This study project aims at providing evidence for a biological mechanism of personality disorder interventions in adolescence by investigating the link between epigenetic changes as an effect of psychotherapy. It investigates the correlation between changes in the methylation of the FKBP5 gene and psychotherapy induced changes in symptoms and functioning.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- adolescents presenting 3 or more criteria for BPD in the Structured clinical interview for the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) axis II personality disorders (SCID-II)
- difficulties to understand or comply with instructions
- psychotic disorders
- pervasive developmental disorders
- severe somatic or neurological disorders
- severe and persistent substance addiction
- elevated risk for complications related to blood sampling
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method change in methylation of the FKBP5 gene after 6 months from baseline change in methylation of the FKBP5 gene
- Secondary Outcome Measures
Name Time Method change in methylation of the FKBP5 gene at month 3 and at month 12 after baseline. change in methylation of the FKBP5 gene