Frequency and change mechanisms of psychotherapy for depression.

Recruiting

Conditions: mechanismen
depressie
ENGLISH: frequency
psychotherapy
depression
mechanismsDUTCH: frequentie
psychotherapie

Registration Number: NL-OMON28796

Lead Sponsor: VU Amsterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 230

Inclusion Criteria

a.DSM V diagnosis of major depression (DSM V persistent depressive disorder will be included)

b.Eligible patients who are on antidepressants and who are willing to discontinue their medications during treatment, prior to participation, will be eligible to participate in the study. Patients already on antidepressants who wish to continue medication are also eligible, but only if their medication use is stable for at least three months before start of treatment

Exclusion Criteria

a.severe mental illness (e.g. schizophrenia)

b.high risk for suicide

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Depression (BDI-II) and quality of life (EQ-5D (5L)) will be the main outcome measures over the course of two years. Besides the completion of a clinical interview at baseline, patients will complete monthly assessments during the first six months of the study. There will be follow-up assessments 9, 12 and 24 months after start of treatment. At 24 months, the LIFE interview will be administered to assess the presence of depressive episodes in the previous year. For the patients who are willing to participate, blood samples will be collected during baseline and end of treatment.

Secondary Outcome Measures

Name	Time	Method
The following secondary study parameters will be involved in the study: Therapeutic alliance (Working Alliance Inventory), cognitive skills (Competencies of Cognitive Therapy Scale/Performance of CT Strategies ), interpersonal skills, recall (patients recall of the last session rated by the therapist), motivation for therapy (Autonomous and Controlled Motivation for Treatment Questionnaire), compliance (amount of no-show and rated by patient and therapist), emotion regulation (Action Control Scale), executive functioning (n-back task), automatic thoughts (Cognition Checklist ), behavioral activation (Behavioral Activation for Depression Scale) and biological factors (brain-derived neurotrophic factor (BDNF), DNA methylation of CpG islands adjacent to promoters I and IV) and oxytocin.