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Compliance and Tolerance to Oral AntiBiotherapy in Osteoarticular Infections (OTABIO)

Recruiting
Conditions
Treatment Adherence and Compliance
Drug-Related Side Effects and Adverse Reactions
Interventions
Other: Tolerance and adherence to oral antibiotics in patients managed for BJI
Registration Number
NCT05202964
Lead Sponsor
Hospices Civils de Lyon
Brief Summary

Bone and joint infections (BJI) are most often bacterial infections that can occur after surgery or de novo. They are rarely fatal in the short term, but are associated with significant morbidity, impaired quality of life and significant costs. Treatment of BJI is based on antibiotic therapy, often combined with surgery. Antibiotic therapy, at high doses, lasts a minimum of 6 weeks. It can be responsible for severe adverse effects. These characteristics (prolonged duration, multiple daily doses, and adverse effects) are known to negatively affect treatment adherence in general.

Detailed Description

Not available

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
60
Inclusion Criteria
  • ≥ 18 years
  • Diagnosis of osteoarticular infection
  • Treatment with at least one oral antibiotic for a minimum expected duration ≥ 6 weeks with an expected end of treatment date
  • Patient who was informed and did not object to participate in the study
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Exclusion Criteria
  • Treatment for BJI with oral antibiotic without end of treatment date
  • treatment for BJI with parenteral antibiotic only
  • patient who doesn't have a telephone number or who doesn't want to give it
  • Adults subject to a legal protection measure
  • Pregnant or breastfeeding women
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Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Arm && Interventions
GroupInterventionDescription
Tolerance and adherence to oral antibiotics in patients managed for BJITolerance and adherence to oral antibiotics in patients managed for BJIPatients having a BJI treated by surgery and taking at least one oral antibiotic after the surgery
Primary Outcome Measures
NameTimeMethod
Percentage of doses taken at 6 weeksAt 6 weeks after surgery

Ratio of the number of doses taken over the theoretical number of doses to be taken over the period

Percentage of doses taken at 3 monthsat 3 months after surgery

Ratio of the number of doses taken over the theoretical number of doses to be taken over the period

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Hospices Civils de Lyon

🇫🇷

Lyon, France

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