Compliance and Tolerance to Oral AntiBiotherapy in Osteoarticular Infections (OTABIO)
- Conditions
- Treatment Adherence and ComplianceDrug-Related Side Effects and Adverse Reactions
- Interventions
- Other: Tolerance and adherence to oral antibiotics in patients managed for BJI
- Registration Number
- NCT05202964
- Lead Sponsor
- Hospices Civils de Lyon
- Brief Summary
Bone and joint infections (BJI) are most often bacterial infections that can occur after surgery or de novo. They are rarely fatal in the short term, but are associated with significant morbidity, impaired quality of life and significant costs. Treatment of BJI is based on antibiotic therapy, often combined with surgery. Antibiotic therapy, at high doses, lasts a minimum of 6 weeks. It can be responsible for severe adverse effects. These characteristics (prolonged duration, multiple daily doses, and adverse effects) are known to negatively affect treatment adherence in general.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 60
- ≥ 18 years
- Diagnosis of osteoarticular infection
- Treatment with at least one oral antibiotic for a minimum expected duration ≥ 6 weeks with an expected end of treatment date
- Patient who was informed and did not object to participate in the study
- Treatment for BJI with oral antibiotic without end of treatment date
- treatment for BJI with parenteral antibiotic only
- patient who doesn't have a telephone number or who doesn't want to give it
- Adults subject to a legal protection measure
- Pregnant or breastfeeding women
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Tolerance and adherence to oral antibiotics in patients managed for BJI Tolerance and adherence to oral antibiotics in patients managed for BJI Patients having a BJI treated by surgery and taking at least one oral antibiotic after the surgery
- Primary Outcome Measures
Name Time Method Percentage of doses taken at 6 weeks At 6 weeks after surgery Ratio of the number of doses taken over the theoretical number of doses to be taken over the period
Percentage of doses taken at 3 months at 3 months after surgery Ratio of the number of doses taken over the theoretical number of doses to be taken over the period
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hospices Civils de Lyon
🇫🇷Lyon, France