A clinical trial to develop new ways of measuring nerve healing after injury

Not Applicable

Completed

• Conditions: Peripheral nerve injury; Injury, Occupational Diseases, Poisoning; Injury of nerve(s) of unspecified body region

• Registration Number: ISRCTN17886637
• Lead Sponsor: The University of Manchester

Brief Summary

2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37704699/ (added 15/09/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-05-21
• Study Completion: 2022-08-04
• Last Update Posted: 3 October 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

1. 18 – 80 years old
2. Peripheral nerve injury of ulnar or median nerve (or both) distal to the elbow
3. Having direct, epineural surgical repair within 1 week after injury
4. Capacity to consent

Exclusion Criteria

1. Outside of stated age range
2. Outside stated location of injury
3. Nerve gap requiring alternative surgical management
4. Lacks capacity to consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measured at date of surgery (or within 7 days post-op), weeks 2 and 6, and months 3, 6 and 12:<br>1. Sweat gland density and epidermal thickness measured by Optical Coherence Tomography<br>2. Regenerative rate and volume of the regenerating nerve measured by high-frequency, three-dimensional ultrasound