eurocognitive Specification of Dysfunctions within Basal Ganglia-Cortex Loops and their Therapeutic Modulation by Deep Brain Stimulation in Patients with Obsessive Compulsive Disorders and Tourette Syndrome - KFO219 TP7

niversitätsklinikum Köln0 个研究点目标入组 35 人开始时间: 2013年10月2日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•For OCD and Tourette patients:
•- chronic course
•- serious expression with subjective distress and significant impairment of psychosocial functioning levels
•- The patient agrees after detailed education about DBS and gives his written informed consent
•- The patient agrees to a detailed evaluation
•For OCD patients:
•- OCD (ICD-10: F42) is the main psychiatric diagnosis
•- strong symptom severity as measured by the YBOCS score
•- At least one documented fully implemented cognitive-behavioral psychotherapy without sufficient success
•- at least two unsuccessful drug therapies with SSRIs or clomipramine for 10 weeks in adequate doses
•- At least one unsuccessful drug augmentation carried out for 10 weeks with one of the following medications: lithium, buspirone or neuroleptics
•For Tourette patients:
•- Tourette Syndrome (ICD-10: F95.2) is the main psychiatric diagnosis
•- strong symptom severity as measured by the score YGTSS
•- Inadequate symptom relief through drug treatment strategies, as a minimum pre-treatment with preparations from all three pharmacological groups listed (neuroleptics, benzodiazepines, alpha-agonists). This should be documented with adequate doses of at least 3-month treatment periods.

•- Acute suicidality
•- Simultaneously or previously existing schizophrenia according to DSM-IV criteria
•- Abuse of or dependence on drugs or alcohol in the last six months
•- Craniocerebral trauma in the anamnesis
•- Clinically relevant internal or neurological diseases
•- Pregnancy or breastfeeding
•- Participation in a clinical trial within the last 30 days before the start of the study
•- Intellectual deficit

发起方

niversitätsklinikum Köln