Comparison of no vasoactive agent with 1-day vasoactive agent after endoscopic variceal ligation in patients with cirrhosis presenting with acute variceal bleeding: an open-label non-inferiority trial - NI

All India Institute Of Medical Sciences, New Delhi, Delhi0 个研究点目标入组 0 人开始时间: 待定最近更新: 2024年5月27日

研究概览

暂无简介。

•1. Cirrhosis (Child A and Child B; CTP score =9) with acute esophageal variceal bleeding for whom adequate endotherapy has been performed
•2. Age between 18-65 years
•3. Willing to participate in the study

•1.Patients already included in the trial presenting with repeat variceal bleeding
•2.Failure to achieve primary hemostasis
•3.Bleeding from cardiofundal varices
•4.Portosinusoidal vascular disorders, and splanchnic vein thrombosis
•5.Patients who have Child C cirrhosis
•6.History of prior TIPS or TIPS thrombosis
•8.Acute-on-chronic liver failure as per the European Association for the Study of Liver definition
•9. Overt Hepatic encephalopathy
•10.Patients with any co-existent malignancy including HCC
•11.Patients with bleeding diathesis.
•12.Pregnant women
•13.Patients with renal dysfunction serum creatinine greater than 2 mg per dL
•14.Patients with sepsis, shock or requiring mechanical ventilation
•15.Contraindications to NSBBs including prior documented hypersensitivity, unacceptable adverse events including hypotension or dizziness and cardiac comorbidities such as heart block

发起方

All India Institute Of Medical Sciences, New Delhi, Delhi