The effects of different vasopressors on the innate immune response during experimental human endotoxemia, a pilot proof-of-principle study - Effects of vasopressors on immune response

Radboud Universitair Medisch Centrum0 个研究点目标入组 40 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

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•- Use of any medication;- Smoking;- Previous spontaneous vagal collapse;- History of atrial or ventricular arrhythmia;- (Family) history of myocardial infarction or stroke under the age of 65 years;- Cardiac conduction abnormalities on the ECG consisting of a 2nd degree atrioventricular block or a complex bundle branch block;- Hypertension (defined as RR systolic >160 or RR diastolic > 90);- Hypotension (defined as RR systolic < 100 or RR diastolic < 50);- Renal impairment (defined as plasma creatinin >120 µmol/l);- Liver enzyme abnormalities or positive hepatitis serology;- Medical history of any disease associated with immune deficiency;- CRP > 20 mg/L, WBC > 12x109/L, or clinically significant acute illness, including infections, within 4 weeks before endotoxin administration;- Participation in a drug trial or donation of blood 3 months prior to the LPS challenge;- Use of recreational drugs within 7 days prior to experiment day;- Recent hospital admission or surgery with general anaesthesia (<3 months)

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