NL-OMON38398
Completed
Not Applicable
Searching for GENes in families with frontotemporal dementia, dementia with Lewy bodies and early onset alzheimer DEMentia - GENDEM
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Alzheimer disease
- Sponsor
- Vrije Universiteit Medisch Centrum
- Enrollment
- 90
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\.Families with (probable) autosomal dominant inheritance of frontotemporal dementia, dementia with Lewy bodies or early onset Alzheimer dementia.
- •\- Families fitting autosomal dominant inheritance:
- •o Frontotemporal dementia or dementia with Lewy bodies in at least three persons in two consecutive generations, or
- •o Alzheimer dementia in at least three persons in two consecutive generations all with an onset below the age of 65 years.
- •\- Families suggestive of autosomal dominant inheritance:
- •o Frontotemporal dementia or dementia with Lewy bodies in at least two persons, or
- •o Alzheimer dementia in at least three persons, 1st or 2nd degree related to each other, of whom at least one has an onset below the age of 65 years, or
- •o Alzheimer dementia in at least two persons, 1st or 2nd degree related to each other, with both an onset below the age of 65 years.;2\. A sufficient understanding of the Dutch language and cognitive abilities to understand questions and procedures of participants or their (legal) representatives
Exclusion Criteria
- •\* Families in which a causal mutation has been identified
- •\* Families that are known to be unwilling to participate in research
- •\* Families in which no DNA of any affected person is or will be available
Outcomes
Primary Outcomes
Not specified
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