NL-OMON38398已完成不适用
Searching for GENes in families with frontotemporal dementia, dementia with Lewy bodies and early onset alzheimer DEMentia - GENDEM
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •1.Families with (probable) autosomal dominant inheritance of frontotemporal dementia, dementia with Lewy bodies or early onset Alzheimer dementia.
- •- Families fitting autosomal dominant inheritance:
- •o Frontotemporal dementia or dementia with Lewy bodies in at least three persons in two consecutive generations, or
- •o Alzheimer dementia in at least three persons in two consecutive generations all with an onset below the age of 65 years.
- •- Families suggestive of autosomal dominant inheritance:
- •o Frontotemporal dementia or dementia with Lewy bodies in at least two persons, or
- •o Alzheimer dementia in at least three persons, 1st or 2nd degree related to each other, of whom at least one has an onset below the age of 65 years, or
- •o Alzheimer dementia in at least two persons, 1st or 2nd degree related to each other, with both an onset below the age of 65 years.;2. A sufficient understanding of the Dutch language and cognitive abilities to understand questions and procedures of participants or their (legal) representatives
排除标准
- •* Families in which a causal mutation has been identified
- •* Families that are known to be unwilling to participate in research
- •* Families in which no DNA of any affected person is or will be available
研究者
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