Sodium accumulation in the skin of children.

Recruiting

Conditions: Fysiologie van natriumbalans
Non-osmotic sodium accumulation
Salt regulation

Registration Number: NL-OMON49448

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 500

Inclusion Criteria

Healthy, male children undergoing a circumcision
Parents / caregivers capable of giving written informed consent and able to
comply with the requirements listed in the informed consent form.

Exclusion Criteria

Unwillingness from the parents to let their child participate in the study
Parents who are not capable of giving written informed consent and able to
comply with the requirements listed in the informed consent form
Contraindication for circumcision
One or both parents who are not capable of reading and understanding the Dutch
patient information letter

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary endpoint will be the sodium content of the skin, expressed in mmol per<br /><br>g dry weight in correlation with cardiovascular risk factors. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Skin GAG composition, residing macrophages, capillary, and lymphatic density<br /><br>(i.e., skin changes that relate to a high sodium-induced BP rise) and BP<br /><br>represent secondary outcome measures.<br /><br><br /><br><br /><br></p><br>