Sodium accumulation in the skin of childre
Recruiting
- Conditions
- (risk for) Cardiovascular disease
- Registration Number
- NL-OMON28774
- Lead Sponsor
- AmsterdamUMC, location AMC
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 500
Inclusion Criteria
Healthy, male children under 12 years of age undergoing a circumcision
- Parents / caregivers capable of giving written informed consent and able to comply with the requirements listed in the informed consent form.
Exclusion Criteria
- Childeren above 12 years of age
- Unwillingness from the parents to let their child participate in the study
- One or both parents who are not capable of reading and understanding the Dutch patient information letter
- Parents who are not capable of giving written informed consent and able to comply with the requirements listed in the informed consent form
- Contraindication for circumcision
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Define the environmental and biological factors that drive skin sodium accumulation according to the novel 3-compartment concept in the skin of children, and to investigate whether these factors are associated with risk factors for future cardiovascular disease.
- Secondary Outcome Measures
Name Time Method The association between skin sodium accumulation and alterations in GAG metabolism and local immune cell infiltration.