A Study of the Efficacy and Safety of Upadacitinib in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Conventional and/or Biologic Therapies

Phase 3

Completed

Conditions: Crohn's Disease

Interventions: Drug: Upadacitinib
Drug: Placebo for Upadacitinib

Registration Number: NCT03345849

Lead Sponsor: AbbVie

Brief Summary: The objective of this study is to evaluate the efficacy and safety of upadacitinib compared to placebo as induction therapy in adults with moderately and severely active Crohn's disease (CD).

Detailed Description: This study includes two parts:

* Part 1: a randomized double-blind placebo-controlled induction period and

* Part 2: an extended treatment period for non-responders from Part 1.

In Part 1, participants will be randomized in a 2:1 ratio to upadacitinib 45 mg once daily (QD) or matching placebo for 12 weeks. The randomization will be stratified by baseline corticosteroid use (yes or no), endoscopic disease severity (Simplified Endoscopic Score for Crohn's disease \[SES-CD\] \< 15 and ≥ 15), and number of prior biologics with prior inadequate response or intolerance (0, 1, \> 1).

Participants who do not achieve clinical response at Week 12 will be able to enroll in Part 2 to receive a double-blind extended treatment with upadacitinib until Week 24. Clinical response is defined as a ≥ 30% decrease in average daily very soft or liquid stool frequency (SF) and/or ≥ 30% decrease in average daily abdominal pain (AP) score (both not worse than Baseline).

Participants who achieve clinical response at Week 12 may be eligible to enter the 52-week, double-blind, maintenance portion of Study M14-430 (NCT03345823).

Recruitment & Eligibility

Status: COMPLETED

Sex: All

Target Recruitment: 526

Inclusion Criteria

Confirmed diagnosis of CD for at least 3 months prior to Baseline.
Confirmed diagnosis of moderate to severe CD as assessed by stool frequency (SF), abdominal pain (AP) score.
Evidence of mucosal inflammation based on the Simplified Endoscopic Score for Crohn's disease (SES-CD) on an endoscopy confirmed by a central reader.
Demonstrated an inadequate response or intolerance to one or more conventional and/or biologic therapies (oral locally acting steroids, intravenous or oral corticosteroids, immunosuppressants or biologic therapies for CD), in the opinion of the investigator.
- Note: Participants who have had inadequate response or intolerance to conventional therapy who have received prior biologic may be enrolled; however, participants must have discontinued the biologic for reasons other than inadequate response or intolerance (e.g., change of insurance, well controlled disease).
If female, participant must meet the contraception recommendations.

Exclusion Criteria

Participant with a current diagnosis of ulcerative colitis or indeterminate colitis.
Participant not on stable doses of CD related antibiotics, oral aminosalicylates, corticosteroids or methotrexate (MTX).
Participant with the following ongoing known complications of CD: abscess (abdominal or peri-anal), symptomatic bowel strictures, fulminant colitis, toxic megacolon, > 2 entire missing segments of the following 5 segments: terminal ileum, right colon, transverse colon, sigmoid and left colon, and rectum, or any other manifestation that might require surgery while enrolled in the study.
Participant with ostomy or ileoanal pouch.
Participant diagnosed with conditions that could interfere with drug absorption including but not limited to short gut or short bowel syndrome.
Screening laboratory and other analyses show abnormal results.

Study & Design

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo for Upadacitinib	Participants will receive placebo once daily for 12 weeks in Part 1. Clinical non-responders will receive 45 mg upadacitinib once daily for 12 weeks in Part 2.
Placebo	Upadacitinib	Participants will receive placebo once daily for 12 weeks in Part 1. Clinical non-responders will receive 45 mg upadacitinib once daily for 12 weeks in Part 2.
Upadacitinib	Upadacitinib	Participants will receive 45 mg upadacitinib once daily for 12 weeks in Part 1. Clinical non-responders will receive 30 mg upadacitinib once daily for 12 weeks in Part 2.

Primary Outcome Measures

Name	Time	Method
Percentage of Participants With Clinical Remission Per Patient-Reported Outcomes (PROs) at Week 12	Week 12	The co-primary endpoint for European Union (EU)/European Medicines Agency (EMA) regulatory purposes was clinical remission defined based on two patient reported outcomes, average daily stool frequency (SF) and average daily abdominal pain score (APS). Clinical remission per PROs was defined as average daily very soft or liquid SF ≤ 2.8 and average daily APS ≤ 1.0 and neither worse than Baseline. Participants recorded APS and the number of very soft or liquid SF daily in an electronic diary. Abdominal pain was rated on a scale from 0 (none) to 3 (severe). The average daily very soft or liquid SF and APS were calculated using the 4-7 most recent useable days of patient-report outcomes (i.e., excluding days with missing entries or associated with endoscopy procedures) out of the last 14 days prior to the Week 12 visit.
Percentage of Participants With Clinical Remission Per Crohn's Disease Activity Index (CDAI) at Week 12	Week 12	The co-primary endpoint for United States (US)/Food and Drug Administration (FDA) regulatory purposes was clinical remission based on CDAI at Week 12. CDAI is a composite instrument that includes participant symptoms evaluated over 7 days (abdominal pain, stool frequency and general well-being), as well as presence of complications (arthritis/arthralgia, iritis/uveitis, erythema nodosum/pyoderma gangrenosum/aphthous stomatitis, anal fissure/fistula/abscess, other fistula, and fever), the use of antidiarrheal medicines, presence of an abdominal mass, hematocrit, and body weight. These items are scored individually, weighted, and do not contribute equally to the overall score. The CDAI is derived from summing up the weighted individual scores of eight items. CDAI approximately ranges from 0 to 600 with higher scores indicating more severe disease. Clinical remission is defined as a CDAI score less than 150.
Percentage of Participants With Endoscopic Response at Week 12	Baseline and Week 12	Endoscopic response at Week 12 was a co-primary endpoint for both the US/FDA and EU/EMA regulatory purposes. Endoscopic response was defined as greater than 50% decrease in Simple Endoscopic Score for Crohn's Disease (SES-CD) from Baseline of the induction study (or for participants with an SES-CD of 4 at Baseline, at least a 2-point reduction from Baseline), as scored by independent external and blinded central readers. The SES-CD evaluates 4 endoscopic variables (ulcer size, ulcerated surface, affected surface, and narrowing, each on a scale from 0 (none) to 3 in 5 segments assessed during ileocolonoscopy (ileum, right colon, transverse colon, sigmoid and left colon, and rectum). The total score is the sum of the 4 endoscopic variable scores and ranges from 0 to 56, where higher scores indicate more severe disease.

Secondary Outcome Measures

Name	Time	Method
Change From Baseline in Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score at Week 12	Baseline and Week 12	The Inflammatory Bowel Disease Questionnaire (IBDQ) is used to assess health-related quality of life (HRQoL) in patients with inflammatory bowel disease. It consists of 32 questions evaluating bowel and systemic symptoms, as well as emotional and social functions. Each question is answered on a scale from 1 (worst) to 7 (best). The total score ranges from 32 to 224 with higher scores indicating better health-related quality of life. A positive change from Baseline indicates improvement.
Change From Baseline in Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-Fatigue) at Week 12	Baseline and Week 12	The FACIT-Fatigue questionnaire is a self-administered patient questionnaire that consists of 13 questions designed to measure the degree of fatigue experienced by participants in the previous 7 days, including physical fatigue (e.g., I feel tired), functional fatigue (e.g., trouble finishing things), emotional fatigue (e.g., frustration), and social consequences of fatigue (e.g., limits social activity). Participants respond to the questions on a scale from 0 (not at all) to 4 (very much). The FACIT-Fatigue score is computed by summing the item scores, after reversing those items that are worded in the negative direction. The FACIT-Fatigue score ranges from 0 to 52, where higher scores represent less fatigue. A positive change from Baseline indicates improvement.
Percentage of Participants Achieving Clinical Response 100 (CR-100) at Week 2	Baseline and Week 2	Clinical response 100 (CR-100) is defined as a decrease of at least 100 points in CDAI from Baseline. CDAI is a composite instrument that includes participant symptoms evaluated over 7 days (abdominal pain, stool frequency and general well-being), as well as presence of complications (arthritis/arthralgia, iritis/uveitis, erythema nodosum/pyoderma gangrenosum/aphthous stomatitis, anal fissure/fistula/abscess, other fistula, and fever), the use of antidiarrheal medicines, presence of an abdominal mass, hematocrit, and body weight. These items are scored individually, weighted, and do not contribute equally to the overall score. The CDAI is derived from summing up the weighted individual scores of eight items. CDAI approximately ranges from 0 to 600 with higher scores indicating more severe disease.
Percentage of Participants With Endoscopic Remission at Week 12	Baseline and Week 12	Endoscopic remission is defined as an SES-CD ≤ 4 and at least 2 point reduction from Baseline and no subscore \> 1 in any individual variable,as scored by independent external and blinded central readers. The SES-CD evaluates 4 endoscopic variables (ulcer size, ulcerated surface, affected surface, and narrowing, each on a scale from 0 (none) to 3 in 5 segments assessed during ileocolonoscopy (ileum, right colon, transverse colon, sigmoid and left colon, and rectum). The total score is the sum of the 4 endoscopic variable scores and ranges from 0 to 56, where higher scores indicate more severe disease.
Percentage of Participants Who Discontinued Corticosteroid Use for Crohn's Disease and Achieved Clinical Remission Per CDAI at Week 12	Week 12	Corticosteroid-free clinical remission is defined as participants who discontinued corticosteroid use for CD and achieved clinical remission per CDAI at Week 12, assessed for participants taking corticosteroids for CD at Baseline. CDAI is a composite instrument that includes participant symptoms evaluated over 7 days (abdominal pain, stool frequency and general well-being), as well as presence of complications (arthritis/arthralgia, iritis/uveitis, erythema nodosum/pyoderma gangrenosum/aphthous stomatitis, anal fissure/fistula/abscess, other fistula, and fever), the use of antidiarrheal medicines, presence of an abdominal mass, hematocrit, and body weight. These items are scored individually, weighted, and do not contribute equally to the overall score. The CDAI is derived from summing up the weighted individual scores of eight items. CDAI approximately ranges from 0 to 600 with higher scores indicating more severe disease. Clinical remission is defined as CDAI score less than 150.
Percentage of Participants With Resolution of Extra-Intestinal Manifestation (EIMs) at Week 12	Week 12	EIMs are defined as manifestations of Crohn's disease in areas of the body other than the digestive tract, including eyes, skin, joints, mouth, and liver. Only participants with any EIM present at Baseline were included in the analysis of resolution of EIMs. Resolution of EIMs was defined as absence of all EIMs at the Week 12 visit.
Percentage of Participants Achieving Clinical Response 100 (CR-100) at Week 12	Baseline and Week 12	Clinical response 100 (CR-100) is defined as a decrease of at least 100 points in CDAI from Baseline. CDAI is a composite instrument that includes participant symptoms evaluated over 7 days (abdominal pain, stool frequency and general well-being), as well as presence of complications (arthritis/arthralgia, iritis/uveitis, erythema nodosum/pyoderma gangrenosum/aphthous stomatitis, anal fissure/fistula/abscess, other fistula, and fever), the use of antidiarrheal medicines, presence of an abdominal mass, hematocrit, and body weight. These items are scored individually, weighted, and do not contribute equally to the overall score. The CDAI is derived from summing up the weighted individual scores of eight items. CDAI approximately ranges from 0 to 600 with higher scores indicating more severe disease.
Percentage of Participants With Clinical Remission Per CDAI at Week 4	Week 4	CDAI is a composite instrument that includes participant symptoms evaluated over 7 days (abdominal pain, stool frequency and general well-being), as well as presence of complications (arthritis/arthralgia, iritis/uveitis, erythema nodosum/pyoderma gangrenosum/aphthous stomatitis, anal fissure/fistula/abscess, other fistula, and fever), the use of antidiarrheal medicines, presence of an abdominal mass, hematocrit, and body weight. These items are scored individually, weighted, and do not contribute equally to the overall score. The CDAI is derived from summing up the weighted individual scores of eight items. CDAI approximately ranges from 0 to 600 with higher scores indicating more severe disease. Clinical remission is defined as CDAI score less than 150.
Percentage of Participants With Hospitalizations Due to Crohn's Disease (CD) During the 12-Week Induction Period	12 weeks	This was assessed by reviewing participant's hospitalization data.
Percentage of Participants With Clinical Remission Per PROs at Week 4	Week 4	Clinical remission per PROs was defined as average daily very soft or liquid SF ≤ 2.8 and average daily APS ≤ 1.0 and neither worse than Baseline. Participants recorded APS and the number of liquid or very soft SF daily in an electronic diary. Abdominal pain was rated on a scale from 0 (none) to 3 (severe). The average daily very soft or liquid SF and APS were calculated using the 4-7 most recent useable days of patient-reported outcomes (i.e., excluding days with missing entries or associated with endoscopy procedures) out of the last 14 days prior to the Week 4 visit.
Percentage of Participants Who Discontinued Corticosteroid Use for Crohn's Disease and Achieved Clinical Remission Per PROs at Week 12	Week 12	Corticosteroid-free clinical remission is defined as participants who discontinued corticosteroid use for CD and achieved clinical remission per PROs at Week 12, assessed for participants taking corticosteroids for CD at Baseline. Clinical remission per PROs was defined as average daily very soft or liquid stool frequency (SF) ≤ 2.8 and average daily APS ≤ 1.0 and neither worse than Baseline. Participants recorded APS and the number of liquid or very soft SF daily in an electronic diary. Abdominal pain was rated on a scale from 0 (none) to 3 (severe). The average daily liquid or very soft SF and APS were calculated using the 4-7 most recent useable days of patient-reported outcomes (i.e., excluding days with missing entries or associated with endoscopy procedures) out of the last 14 days prior to the Week 12 visit.

Trial Locations

Locations (432): Fiona Stanley Hospital /ID# 171513
🇦🇺
Murdoch, Western Australia, Australia
Velocity Clinical Research - Salt Lake City /ID# 166076
🇺🇸
West Jordan, Utah, United States
Rush University Medical Center /ID# 165497
🇺🇸
Chicago, Illinois, United States
Optimed Research, Ltd. /ID# 205624
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Columbus, Ohio, United States
Johns Hopkins University School of Medicine /ID# 211941
🇺🇸
Baltimore, Maryland, United States
MHAT Trakia /ID# 201679
🇧🇬
Stara Zagora, Bulgaria
Air Force Specialized Hospital /ID# 170996
🇪🇬
Cairo, Egypt
Tokyo Women's Medical University Hospital /ID# 205980
🇯🇵
Shinjuku-ku, Tokyo, Japan
Kanazawa University Hospital /ID# 169218
🇯🇵
Kanazawa-shi, Ishikawa, Japan
Iwate Medical University Uchimaru Medical Center /ID# 202464
🇯🇵
Morioka-shi, Iwate, Japan
Okayama University Hospital /ID# 167356
🇯🇵
Okayama-shi, Okayama, Japan
Tokitokai Tokito clinic /ID# 165962
🇯🇵
Saitama-shi, Saitama, Japan
Shiga University of Medical Science Hospital /ID# 167129
🇯🇵
Otsu-shi, Shiga, Japan
Toyama Prefectural Central Hospital /ID# 217834
🇯🇵
Toyama-shi, Toyama, Japan
Medisch Spectrum Twente /ID# 170298
🇳🇱
Enschede, Netherlands
Hamamatsu University Hospital /ID# 224352
🇯🇵
Hamamatsu-shi, Shizuoka, Japan
Hospital Sultanah Bahiyah /ID# 202626
🇲🇾
Alor Setar, Kedah, Malaysia
Tokai University Hachioji Hospital /ID# 165967
🇯🇵
Hachioji-shi, Tokyo, Japan
City Clinical Hospital No. 31 /ID# 208868
🇷🇺
St. Petersburg, Russian Federation
Military Medical Academy /ID# 168783
🇷🇸
Belgrade, Beograd, Serbia
KL Ling Gastroenterology and Liver Clinic /ID# 217962
🇸🇬
Singapore, Singapore
KM Management, spol. s.r.o. /ID# 170201
🇸🇰
Nitra, Slovakia
Warrington and Halton Hospitals NHS Foundation Trust /ID# 171383
🇬🇧
Warrington, Cheshire West And Chester, United Kingdom
University Clinical Center Tuzla /ID# 210325
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Tuzla, Tuzlanski, Bosnia and Herzegovina
AZ Sint-Lucas /ID# 200302
🇧🇪
Gent, Belgium
University Clinical Centre of the Republic of Srpska /ID# 208051
🇧🇦
Banja Luka, Republika Srpska, Bosnia and Herzegovina
UMHAT Kaspela EOOD /ID# 167613
🇧🇬
Plovdiv, Bulgaria
UHC Split /ID# 171191
🇭🇷
Split, Croatia
The First Hospital of Jilin University /ID# 206868
🇨🇳
Changchun, Jilin, China
The Sixth Affiliated Hosp Sun /ID# 204077
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Guangzhou, Guangdong, China
QEII - Health Sciences Centre /ID# 169307
🇨🇦
Halifax, Nova Scotia, Canada
CISSS de Chaudière-Appalaches, Hôpital Hotel-Dieu de Lévis /ID# 166969
🇨🇦
Levis, Quebec, Canada
CIUSSS de l'Estrie - CHUS /ID# 170940
🇨🇦
Sherbrooke, Quebec, Canada
ResTrial s.r.o. /ID# 208653
🇨🇿
Praha, Czechia
Centre Hospitalier de l'Universite de Montreal - CRCHUM /ID# 170120
🇨🇦
Montreal, Quebec, Canada
Hospital Nossa Senhora das Graças /ID# 166863
🇧🇷
Curitiba, Parana, Brazil
Clinical Center University of Sarajevo /ID# 203887
🇧🇦
Sarajevo, Bosnia and Herzegovina
Hospital Guillermo Grant Benavente de Concepción /ID# 212423
🇨🇱
Concepción, Chile
Zhongshan Hospital Xiamen University /ID# 204984
🇨🇳
Xiamen, Fujian, China
University of Calgary /ID# 166974
🇨🇦
Calgary, Alberta, Canada
Upeclin Fmb - Unesp /Id# 166867
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Botucatu, Sao Paulo, Brazil
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 166866
🇧🇷
Ribeirão Preto, Sao Paulo, Brazil
Scott Shulman Medicine Professional Corporation /ID# 169066
🇨🇦
North Bay, Ontario, Canada
Nanfang Hospital of Southern Medical University /ID# 204083
🇨🇳
Guangzhou, Guangdong, China
CHU Grenoble - Hopital Michallon /ID# 219034
🇫🇷
La Tronche, France
ARTROSCAN s.r.o. /ID# 200790
🇨🇿
Ostrava, Czechia
Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 166852
🇧🇷
Goiânia, Goias, Brazil
Ottawa Hospital Research Institute /ID# 212414
🇨🇦
Ottawa, Ontario, Canada
Universitatsklinikum Mannheim /ID# 168759
🇩🇪
Mannheim, Baden-Wuerttemberg, Germany
The First Affiliated Hospital, Sun Yat-sen University /ID# 205228
🇨🇳
Guangzhou, Guangdong, China
Nemocnice Ceske Budejovice a.s. /ID# 224389
🇨🇿
Ceske Budejovice, Czechia
Kaiser Clinica e Hospital Dia /ID# 166865
🇧🇷
Sao Jose Do Rio Preto, Sao Paulo, Brazil
Taunton Surgical Centre /ID# 168043
🇨🇦
Oshawa, Ontario, Canada
Universitaetsklinikum Ulm /ID# 203560
🇩🇪
Ulm, Baden-Wuerttemberg, Germany
Herlev Hospital /ID# 202423
🇩🇰
Herlev, Hovedstaden, Denmark
London Health Sciences Center /ID# 221038
🇨🇦
London, Ontario, Canada
The second Affiliated hospital of Zhejiang University school of Medicine /ID# 204073
🇨🇳
Hangzhou, Zhejiang, China
Faculdade de Medicina do ABC /ID# 208323
🇧🇷
Santo André, Sao Paulo, Brazil
Klinicki bolnicki centar Zagreb /ID# 171203
🇭🇷
Zagreb, Grad Zagreb, Croatia
Clinique Jules Verne /ID# 219073
🇫🇷
Nantes, France
CH Valenciennes /ID# 219035
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Valenciennes, France
Agaplesion Markus Krankenhaus /ID# 168758
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Frankfurt am Main, Germany
Medizinisches Versorgungszentrum Portal 10 /ID# 200214
🇩🇪
Muenster, Germany
Hepato-Gastroenterologie HK, s.r.o. /ID# 171401
🇨🇿
Hradec Kralove, Czechia
Universitaetsklinikum Erlangen /ID# 203552
🇩🇪
Erlangen, Bayern, Germany
Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 209564
🇪🇬
Alexandria, Egypt
West Tallinn Central Hospital /ID# 202785
🇪🇪
Tallinn, Estonia
Universitaetsmedizin Essen St. Josef Krankenhaus Werden /ID# 203570
🇩🇪
Essen, Germany
Universitaetsklinikum Frankfurt /ID# 203566
🇩🇪
Frankfurt am Main, Hessen, Germany
Policlinico San Martino/Univer /ID# 168191
🇮🇹
Genova, Italy
Gastroenterologie am Mexikoplatz /ID# 203575
🇩🇪
Berlin, Germany
University General Hospital of Heraklion PA.G.N.I /ID# 167044
🇬🇷
Heraklion, Kriti, Greece
Rabin Medical Center /ID# 202636
🇮🇱
Petakh Tikva, Israel
Fondazione PTV Policlinico Tor Vergata /ID# 168188
🇮🇹
Rome, Roma, Italy
A.O. Per L'Emergenza Cannizzaro /ID# 168190
🇮🇹
Catania, Italy
Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 168182
🇮🇹
Rome, Roma, Italy
Soroka University Medical Center /ID# 169913
🇮🇱
Be'er Sheva, HaDarom, Israel
Kaplan Medical Center /ID# 170276
🇮🇱
Rehovot, Israel
Kyoto University Hospital /ID# 169889
🇯🇵
Kyoto-shi, Kyoto, Japan
Kyungpook National University Hospital /ID# 207019
🇰🇷
Daegu, Korea, Republic of
Asahikawa Medical University Hospital /ID# 167120
🇯🇵
Asahikawa-shi, Hokkaido, Japan
Imamura General Hospital /ID# 227137
🇯🇵
Kagoshima-shi, Kagoshima, Japan
Japanese Red Cross Kyoto Daiichi Hosital /ID# 165972
🇯🇵
Kyoto-shi, Kyoto, Japan
Inje University Haeundae Hospital /ID# 202630
🇰🇷
Busan, Korea, Republic of
VCA Polyclinic Aura /ID# 169498
🇱🇻
Riga, Latvia
LLC Medical Center /ID# 209236
🇷🇺
Novosibirsk, Novosibirskaya Oblast, Russian Federation
Tan Tock Seng Hospital /ID# 203160
🇸🇬
Singapore, Singapore
Hospital Universitario de Girona Doctor Josep Trueta /ID# 202645
🇪🇸
Girona, Spain
Malopolskie Centrum Kliniczne /ID# 202167
🇵🇱
Krakow, Malopolskie, Poland
Hospital Universitari Son Espases /ID# 201998
🇪🇸
Palma de Mallorca, Illes Balears, Spain
Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 200607
🇵🇹
Ponte de Lima, Viana Do Castelo, Portugal
Centro Hospitalar Universitario de Sao Joao, EPE /ID# 170248
🇵🇹
Porto, Portugal
Hospital Universitario A Coruna - CHUAC /ID# 203910
🇪🇸
A Coruna, Spain
Mindful Medical Research /ID# 203358
🇵🇷
San Juan, Puerto Rico
Univ Medical Ctr Ljubljana /ID# 217795
🇸🇮
Ljubljana, Slovenia
Acibadem Kozyatagi Hospital /ID# 209406
🇹🇷
Kadikoy, Istanbul, Turkey
Hospital Universitario La Paz /ID# 201994
🇪🇸
Madrid, Spain
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 171332
🇹🇷
Istanbul, Turkey
Lenasia Clinical Trial Centre /ID# 205145
🇿🇦
Johannesburg, Gauteng, South Africa
Hospital Egas Moniz /ID# 170253
🇵🇹
Lisbon, Porto, Portugal
Hospital Garcia de Orta, EPE /ID# 170241
🇵🇹
Almada, Portugal
Immanuel Kant Baltic Federal University /ID# 203811
🇷🇺
Kaliningrad, Kaliningradskaya Oblast, Russian Federation
Euromedservice /ID# 206610
🇷🇺
Pushkin, Russian Federation
Gleneagles Medical Centre /ID# 206531
🇸🇬
Singapore, Singapore
Universitätsspital Zürich /ID# 170998
🇨🇭
Zürich, Zuerich, Switzerland
Hospital Clinic de Barcelona /ID# 201990
🇪🇸
Barcelona, Spain
Kharkiv City Clinical Hospital No.2 n.a. Prof. O.O. Shalimov /ID# 167907
🇺🇦
Kharkiv, Ukraine
CNE Vinnytsya Regional Clinical Hospital named after N.I.Pirogov /ID# 222110
🇺🇦
Vinnytsia, Ukraine
Sisli Etfal Train & Res Hosp /ID# 171334
🇹🇷
Sisli, Turkey
Istanbul University Istanbul Medical Faculty /ID# 171364
🇹🇷
Istanbul, Turkey
Taichung Veterans General Hospital /ID# 169790
🇨🇳
Taichung, Taiwan
MNI KRC Kyiv Regional Clinical Hospital /ID# 202454
🇺🇦
Kyiv, Ukraine
Mersin University Medical /ID# 171338
🇹🇷
Mersin, Turkey
Gazi Universitesi Tip Fakultes /ID# 217444
🇹🇷
Yenimahalle, Turkey
Hospital Universitario Virgen Macarena /ID# 201993
🇪🇸
Sevilla, Spain
The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 169075
🇬🇧
Newcastle Upon Tyne, United Kingdom
The Royal Wolverhampton NHS Trust /ID# 171382
🇬🇧
Wolverhampton, United Kingdom
Karolinska University Hospital Solna /ID# 224488
🇸🇪
Solna, Stockholms Lan, Sweden
Inselspital, Universitätsspital Bern /ID# 170997
🇨🇭
Bern, Switzerland
China Medical University Hospital /ID# 169791
🇨🇳
Taichung City, Taiwan
Medical Centre of "Ukrainian German Antiulcer Gastroenterology Centre BYK-KYIV" /ID# 203738
🇺🇦
Kyiv, Kyivska Oblast, Ukraine
Mustafa Kemal University Medic /ID# 171336
🇹🇷
Hatay, Turkey
Sodra Alvsborgs sjukhus /ID# 203077
🇸🇪
Boras, Vastra Gotalands Lan, Sweden
National Taiwan University Hospital /ID# 169792
🇨🇳
Taipei City, Taiwan
Lviv Railway Clinical Hospital of branch Healthcare Centers of Public Joint Stoc /ID# 167908
🇺🇦
Lviv, Ukraine
Ankara Univ Medical Faculty /ID# 206409
🇹🇷
Ankara, Turkey
University Hospitals Birmingham NHS Foundation Trust /ID# 169070
🇬🇧
Birmingham, United Kingdom
King's College Hospital NHS Foundation Trust /ID# 169072
🇬🇧
London, United Kingdom
Royal United Hospitals Bath /ID# 169074
🇬🇧
Bath, United Kingdom
The Dudley Group NHS Foundation Trust /ID# 169069
🇬🇧
Dudley, United Kingdom
Stockport NHS foundation trust /ID# 208719
🇬🇧
Stockport, United Kingdom
St George's University Hospitals NHS Foundation Trust /ID# 205552
🇬🇧
Tooting, United Kingdom
Taunton and Somerset NHS Foundation Trust /ID# 209665
🇬🇧
Taunton, United Kingdom
CliniCore International, LLC /ID# 164902
🇺🇸
Houston, Texas, United States
Baylor College of Medicine - Baylor Medical Center /ID# 164947
🇺🇸
Houston, Texas, United States
Ucsd /Id# 164910
🇺🇸
San Diego, California, United States
Las Vegas Medical Research /ID# 168588
🇺🇸
Las Vegas, Nevada, United States
University of Cincinnati /ID# 164825
🇺🇸
Cincinnati, Ohio, United States
Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 204081
🇨🇳
Wuhan, Hubei, China
The First Affiliated Hospital of Nanchang University /ID# 204092
🇨🇳
Nanchang, Jiangxi, China
Beijing Friendship Hospital /ID# 204173
🇨🇳
Beijing, China
Nanjing Drum Tower Hospital /ID# 204900
🇨🇳
Nanjing, Jiangsu, China
Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 204091
🇨🇳
Shanghai, Shanghai, China
Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 204076
🇨🇳
Hangzhou, Zhejiang, China
The Second Xiangya Hospital of Central South University /ID# 204082
🇨🇳
Changsha, China
Duplicate_Tianjin Med Univ General Hosp /ID# 206994
🇨🇳
Tianjin, China
Tongji Hospital Tongji Medical College of HUST /ID# 204088
🇨🇳
Wuhan, China
Hospital de Clinicas de Porto Alegre /ID# 166862
🇧🇷
Porto Alegre, Rio Grande Do Sul, Brazil
Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 168757
🇩🇪
Kiel, Schleswig-Holstein, Germany
IRCCS Ospedale Sacro Cuore Don Calabria /ID# 168186
🇮🇹
Negrar, Verona, Italy
East View Medical Research, LLC /ID# 171176
🇺🇸
Mobile, Alabama, United States
CB Flock Research Corporation /ID# 166185
🇺🇸
Mobile, Alabama, United States
Delsol Research Management, Ll /Id# 170145
🇺🇸
Chandler, Arizona, United States
HonorHealth Research Institute - Shea /ID# 164821
🇺🇸
Scottsdale, Arizona, United States
Arizona Arthritis & Rheumatology Research, PLLC /ID# 164803
🇺🇸
Sun City, Arizona, United States
Southern California Res. Ctr. /ID# 169655
🇺🇸
Coronado, California, United States
Citrus Valley Gastroenterology /ID# 166173
🇺🇸
Covina, California, United States
Hoag Memorial Hosp Presbyterian /ID# 222540
🇺🇸
Irvine, California, United States
Gastrointestinal Biosciences Clinical Trials, LLC /ID# 164762
🇺🇸
Los Angeles, California, United States
Facey Medical Foundation /ID# 203136
🇺🇸
Mission Hills, California, United States
United Medical Doctors - Murrieta /ID# 164945
🇺🇸
Murrieta, California, United States
Medical Assoc Research Grp /ID# 169706
🇺🇸
San Diego, California, United States
Peak Gastroenterology Associates, PC /ID# 170143
🇺🇸
Colorado Springs, Colorado, United States
Delta Waves, Inc. /ID# 164776
🇺🇸
Colorado Springs, Colorado, United States
Western States Clinical Res /ID# 164760
🇺🇸
Wheat Ridge, Colorado, United States
Medical Research Center of CT /ID# 164926
🇺🇸
Hamden, Connecticut, United States
Encore Borland-Groover Clinical Research /Id# 203499
🇺🇸
Jacksonville, Florida, United States
Clinical Research of West Florida, Inc /ID# 205827
🇺🇸
Clearwater, Florida, United States
Clinical Research of West Florida, Inc /ID# 208118
🇺🇸
Clearwater, Florida, United States
Advanced Research - Coral Springs /ID# 218021
🇺🇸
Coral Springs, Florida, United States
Crystal Pharmacology Research /ID# 166081
🇺🇸
Miami, Florida, United States
Coral Research Clinic /ID# 164890
🇺🇸
Miami, Florida, United States
Ctr for Advanced Gastroenterol /ID# 165353
🇺🇸
Maitland, Florida, United States
Advanced Research Institute, Inc /ID# 164921
🇺🇸
New Port Richey, Florida, United States
Gastroenterology Associates of Central Georgia, LLC /ID# 165478
🇺🇸
Macon, Georgia, United States
Gastroenterology Consultants PC - Roswell /ID# 218220
🇺🇸
Roswell, Georgia, United States
Atlanta Gastroenterology Spec /ID# 164799
🇺🇸
Suwanee, Georgia, United States
Treasure Valley Medical Research /ID# 215032
🇺🇸
Boise, Idaho, United States
MediSphere Medical Research Center /ID# 166175
🇺🇸
Evansville, Indiana, United States
University of Chicago Medicine /ID# 165503
🇺🇸
Chicago, Illinois, United States
DuPage Medical Group /ID# 205328
🇺🇸
Downers Grove, Illinois, United States
Indianapolis Gastroenterology /ID# 164938
🇺🇸
Indianapolis, Indiana, United States
University of Iowa Hospitals and Clinics /ID# 165436
🇺🇸
Iowa City, Iowa, United States
Tri-State Gastroenterology /ID# 165496
🇺🇸
Crestview Hills, Kentucky, United States
CroNOLA, LLC /ID# 164823
🇺🇸
Houma, Louisiana, United States
Louisana Research Center, LLC /ID# 164894
🇺🇸
Shreveport, Louisiana, United States
Lahey Hospital and Medical Center /ID# 214726
🇺🇸
Burlington, Massachusetts, United States
MGG Group Co, Inc.Chevy Chase Clinical Research /ID# 164935
🇺🇸
Chevy Chase, Maryland, United States
Gastro Center of Maryland /ID# 171161
🇺🇸
Columbia, Maryland, United States
Digestive Health Associates (DHA) - Farmington Hills /ID# 205793
🇺🇸
Farmington Hills, Michigan, United States
Center for Digestive Health /ID# 164822
🇺🇸
Troy, Michigan, United States
Clin Res Inst of Michigan, LLC /ID# 170133
🇺🇸
Troy, Michigan, United States
Southern Therapy and Advanced Research (STAR) LLC /ID# 165343
🇺🇸
Jackson, Mississippi, United States
AGA Clinical Research Associates, LLC /ID# 164769
🇺🇸
Egg Harbor Township, New Jersey, United States
Rutgers Robert Wood Johnson /ID# 166073
🇺🇸
New Brunswick, New Jersey, United States
Advantage Clinical Trials /ID# 168546
🇺🇸
Bronx, New York, United States
Montefiore Medical Center - Moses Campus /ID# 166193
🇺🇸
Bronx, New York, United States
NY Scientific /ID# 164931
🇺🇸
Brooklyn, New York, United States
NYU Langone Long Island Clinical Research Associates /ID# 164927
🇺🇸
Lake Success, New York, United States
The Mount Sinai Hospital /ID# 170257
🇺🇸
New York, New York, United States
Columbia Univ Medical Center /ID# 164782
🇺🇸
New York, New York, United States
Atrium Health Carolinas Medical Center /ID# 164932
🇺🇸
Charlotte, North Carolina, United States
Richmond University Medical Center /ID# 201857
🇺🇸
Staten Island, New York, United States
Gastoenterology Group of Rochester /ID# 166177
🇺🇸
Rochester, New York, United States
PMG Research of Charlotte /ID# 171160
🇺🇸
Charlotte, North Carolina, United States
Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 164904
🇺🇸
Raleigh, North Carolina, United States
Plains Clinical Research Center, LLC /ID# 170140
🇺🇸
Fargo, North Dakota, United States
Gastro Health Research /ID# 164791
🇺🇸
Cincinnati, Ohio, United States
Cleveland Clinic Main Campus /ID# 209231
🇺🇸
Cleveland, Ohio, United States
Hometown Urgent Care and Resea /ID# 201291
🇺🇸
Dayton, Ohio, United States
Dayton Gastroenterology, Inc. /ID# 167627
🇺🇸
Englewood, Ohio, United States
Great Lakes Medical Research, LLC /ID# 202010
🇺🇸
Mentor, Ohio, United States
Options Health Research, LLC /ID# 164820
🇺🇸
Tulsa, Oklahoma, United States
Healthcare Research Consultant /ID# 166195
🇺🇸
Tulsa, Oklahoma, United States
University of Pennsylvania /ID# 168430
🇺🇸
Philadelphia, Pennsylvania, United States
Gastroenterology Associates, P.A. of Greenville /ID# 164771
🇺🇸
Greenville, South Carolina, United States
Rapid City Medical Center - GI Research /ID# 201735
🇺🇸
Rapid City, South Dakota, United States
Gastro One /ID# 164826
🇺🇸
Germantown, Tennessee, United States
TX Clinical Research Institute /ID# 164896
🇺🇸
Arlington, Texas, United States
East Tennessee Research Institute /ID# 203613
🇺🇸
Johnson City, Tennessee, United States
Inquest Clinical Research /ID# 164785
🇺🇸
Baytown, Texas, United States
Texas Digestive Disease Consultants /ID# 209953
🇺🇸
Cedar Park, Texas, United States
Texas Digestive Disease Consultants /ID# 209801
🇺🇸
Cedar Park, Texas, United States
Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 170144
🇺🇸
Dallas, Texas, United States
Centex Studies, Inc. - Houston /ID# 201214
🇺🇸
Houston, Texas, United States
GI Specialists of Houston /ID# 202339
🇺🇸
Houston, Texas, United States
Caprock Gastro Research, LLC /ID# 215438
🇺🇸
Lubbock, Texas, United States
Carl R. Meisner Medical Clinic /ID# 201061
🇺🇸
Sugar Land, Texas, United States
Tyler Research Institute, LLC /ID# 168687
🇺🇸
Tyler, Texas, United States
HP Clinical Research /ID# 164933
🇺🇸
Bountiful, Utah, United States
Gastro Health & Nutrition - Victoria /ID# 167812
🇺🇸
Victoria, Texas, United States
Advanced Research Institute /ID# 164784
🇺🇸
Ogden, Utah, United States
Washington Gastroenterology /ID# 164824
🇺🇸
Bellevue, Washington, United States
Virginia Mason Medical Center /ID# 164913
🇺🇸
Seattle, Washington, United States
The Vancouver Clinic, INC. PS /ID# 164918
🇺🇸
Vancouver, Washington, United States
Allegiance Research Specialists /ID# 165346
🇺🇸
Wauwatosa, Wisconsin, United States
Cardio Alem /ID# 211285
🇦🇷
San Isidro, Buenos Aires, Argentina
Hospital Italiano de Buenos Aires /ID# 215541
🇦🇷
Ciudad Autonoma Buenos Aires, Ciuadad Autonoma De Buenos Aires, Argentina
Cemic /Id# 169182
🇦🇷
Ciudad Autonoma de Buenos Aire, Ciuadad Autonoma De Buenos Aires, Argentina
Hospital Provincial del Centenario /ID# 171252
🇦🇷
Rosario, Santa Fe, Argentina
Hospital Privado Univesitario /ID# 169230
🇦🇷
Cordoba, Argentina
Concord Repatriation General Hospital /ID# 171512
🇦🇺
Concord, New South Wales, Australia
Coral Sea Clinical Research institute /ID# 212988
🇦🇺
North Mackay, Queensland, Australia
Mater Misericordiae Limited /ID# 204909
🇦🇺
South Brisbane, Queensland, Australia
Royal Adelaide Hospital /ID# 171514
🇦🇺
Adelaide, South Australia, Australia
Medizinische Universitaet Wien /ID# 169465
🇦🇹
Vienna, Wien, Austria
UCL Saint-Luc /ID# 200303
🇧🇪
Woluwe-Saint-Lambert, Bruxelles-Capitale, Belgium
CHU de Liege Sart Tilman /ID# 217534
🇧🇪
Liège, Liege, Belgium
Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 206741
🇩🇪
Saarbrücken, Saarland, Germany
Universitaetsklinikum Halle (Saale) /ID# 207455
🇩🇪
Halle (Saale), Germany
General Hospital of Chest Diseases of Athens SOTIRIA /ID# 202104
🇬🇷
Athens, Attiki, Greece
Azienda Ospedaliera San Camillo Forlanini /ID# 168184
🇮🇹
Rome, Lazio, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 168187
🇮🇹
Bologna, Italy
A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 168189
🇮🇹
Palermo, Italy
National Hospital Organization Hirosaki General Medical Center /ID# 165961
🇯🇵
Hirosaki-shi, Aomori, Japan
Sapporo IBD Clinic /ID# 223561
🇯🇵
Sapporo-shi, Hokkaido, Japan
Aoyama Clinic /ID# 166009
🇯🇵
Kobe-shi, Hyogo, Japan
Sapporo Medical University Hospital /ID# 167124
🇯🇵
Sapporo-shi, Hokkaido, Japan
Idzuro Imamura Hospital /ID# 206654
🇯🇵
Kagoshima-shi, Kagoshima, Japan
Yokohama City University Medical Center /ID# 167128
🇯🇵
Yokohama shi, Kanagawa, Japan
Sameshima Hospital /ID# 206675
🇯🇵
Kagoshima-shi, Kagoshima, Japan
Nara Medical University Hospital /ID# 169219
🇯🇵
Kashihara-shi, Nara, Japan
Wakayama Medical University Hospital /ID# 169482
🇯🇵
Wakayama-shi, Wakayama, Japan
Kangbuk Samsung Hospital /ID# 167586
🇰🇷
Seoul, Seoul Teugbyeolsi, Korea, Republic of
Hayang University GuriHospital /ID# 167587
🇰🇷
Guri, Gyeonggido, Korea, Republic of
Morales Vargas Centro de Investigacion S.C. /ID# 203494
🇲🇽
Leon, Guanajuato, Mexico
Onze Lieve Vrouwe Gasthuis /ID# 166929
🇳🇱
Amsterdam, Netherlands
Clinica GASTRO MED SRL /ID# 206369
🇷🇴
Cluj-Napoca, Cluj, Romania
Institutul Clinic Fundeni /ID# 167817
🇷🇴
Sector 2, Bucuresti, Romania
Republican hospital named after V.A. Baranov /ID# 206488
🇷🇺
Petrozavodsk, Russian Federation
X7 Clinical Research Center /ID# 216350
🇷🇺
Saint Petersburg, Russian Federation
University Clinical Center Serbia /ID# 168215
🇷🇸
Belgrade, Beograd, Serbia
Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 169958
🇸🇰
Banska Bystrica, Slovakia
Wits Clinical Research Site /ID# 170852
🇿🇦
Johannesburg, Gauteng, South Africa
Dr JP Wright /ID# 170887
🇿🇦
Cape Town, Western Cape, South Africa
Private Practice Dr MN Rajabally /ID# 169853
🇿🇦
Cape Town, Western Cape, South Africa
Hospital Universitario de Salamanca /ID# 206358
🇪🇸
Salamanca, Spain
Hospital Clinico Universitario de Valencia /ID# 209657
🇪🇸
Valencia, Spain
Hospital Universitario y Politecnico La Fe /ID# 201992
🇪🇸
Valencia, Spain
Inonu Universitesi Turgut Ozal /ID# 201268
🇹🇷
Battalgazi/malatya, Turkey
Kyiv Municipal Clinical Hospital #18 /ID# 207889
🇺🇦
Kyiv, Ukraine
Nordsjaellands Hospital /ID# 202424
🇩🇰
Hilleroed, Hovedstaden, Denmark
Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 202425
🇩🇰
Hvidovre, Hovedstaden, Denmark
Duplicate_Sjaellands Universitets Hospital /ID# 209445
🇩🇰
Roskilde, Sjælland, Denmark
Univ of California San Francis /ID# 164944
🇺🇸
San Francisco, California, United States
Digestive Disease Specialists /ID# 201064
🇺🇸
Oklahoma City, Oklahoma, United States
Quality Medical Research /ID# 205263
🇺🇸
Nashville, Tennessee, United States
Vanderbilt University Medical Center /ID# 164946
🇺🇸
Nashville, Tennessee, United States
Clinical Associates in Research Therapeutics of America, LLC /ID# 164786
🇺🇸
San Antonio, Texas, United States
Southern Star Research Institute, LLC /ID# 169755
🇺🇸
San Antonio, Texas, United States
Duplicate_Care Access Research /ID# 164794
🇺🇸
Salt Lake City, Utah, United States
Hallands Hospital Halmstad /ID# 170828
🇸🇪
Halmstad, Hallands Lan, Sweden
Alingsas lasarett /ID# 170826
🇸🇪
Alingsas, Vastra Gotalands Lan, Sweden
Sahlgrenska University Hospital /ID# 169171
🇸🇪
Gothenburg, Vastra Gotalands Lan, Sweden
Istituto Clinico Humanitas /ID# 168185
🇮🇹
Rozzano, Milano, Italy
ASST Fatebenefratelli Sacco - Ospedale Fatebenefratelli e Oftalmico /ID# 168181
🇮🇹
Milano, Italy
ASST Grande Ospedale Metropolitano Niguarda /ID# 170849
🇮🇹
Milano, Italy
Azienda Ospedaliero-Universitaria di Modena /ID# 201897
🇮🇹
Modena, Italy
Azienda Ospedaliero Universitaria Pisana-Stabilimento di Cisanello /ID# 202421
🇮🇹
Pisa, Italy
University of Alberta - Zeidler Ledcor Centre /ID# 166971
🇨🇦
Edmonton, Alberta, Canada
South Edmonton Gastroenterology Research Clinic /ID# 166978
🇨🇦
Edmonton, Alberta, Canada
Royal Victoria Hospital / McGill University Health Centre /ID# 170119
🇨🇦
Montreal, Quebec, Canada
Medicor Research Inc /ID# 166979
🇨🇦
Sudbury, Ontario, Canada
Toronto Digestive Disease Asso /ID# 166972
🇨🇦
Vaughan, Ontario, Canada
Mayo Clinic - Rochester /ID# 164783
🇺🇸
Rochester, Minnesota, United States
Quality Clinical Research Inc. /ID# 170137
🇺🇸
Omaha, Nebraska, United States
Duplicate_CHI Nebraska d/b/a CHI Health /ID# 168578
🇺🇸
Omaha, Nebraska, United States
Hospital Juan Ramon Jimenez /ID# 201995
🇪🇸
Huelva, Spain
Yonsei University Health System Severance Hospital /ID# 167590
🇰🇷
Seoul, Seoul Teugbyeolsi, Korea, Republic of
CHA University Bundang Medical Center /ID# 167592
🇰🇷
Seongnam si, Gyeonggido, Korea, Republic of
Dong-A University Hospital /ID# 167591
🇰🇷
Busan, Korea, Republic of
Samsung Medical Center /ID# 167588
🇰🇷
Seoul, Korea, Republic of
Pusan National University Hospital /ID# 167589
🇰🇷
Busan, Korea, Republic of
United Health Services Hospitals, Inc /ID# 217485
🇺🇸
Johnson City, New York, United States
Gedyt /ID# 210020
🇦🇷
Ciudad Autonoma de Buenos Aire, Ciuadad Autonoma De Buenos Aires, Argentina
Clinical Research Trials of Florida, Inc. /ID# 203485
🇺🇸
Tampa, Florida, United States
AdventHealth Tampa /ID# 171167
🇺🇸
Tampa, Florida, United States
South Eastern Health and Social Care Trust /ID# 205323
🇬🇧
Belfast, Antrim, United Kingdom
The Ohio State University /ID# 170141
🇺🇸
Columbus, Ohio, United States
Chung-Ang University Hostipal /ID# 207018
🇰🇷
Seoul, Korea, Republic of
Duplicate_Second MHAT Sofia /ID# 167614
🇧🇬
Sofia, Bulgaria
CTR Estudios Clinicos /ID# 203941
🇨🇱
Providencia, Chile
Zadar General Hospital /ID# 205536
🇭🇷
Zadar, Croatia
Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 171012
🇪🇬
Alexandria, Egypt
Mentahaz Maganorvosi Kozpont /ID# 201895
🇭🇺
Szekesfehervar, Hungary
Toho University Sakura Medical Center /ID# 165963
🇯🇵
Sakura-shi, Chiba, Japan
Fukuoka University Chikushi Hospital /ID# 214404
🇯🇵
Chikushino-shi, Fukuoka, Japan
Niigata University Medical & Dental Hospital /ID# 170045
🇯🇵
Niigata-shi, Niigata, Japan
Ishida Clinic of IBD and Gastroenterology /ID# 167121
🇯🇵
Oita-shi, Oita, Japan
NHO Shizuoka Medical Center /ID# 167125
🇯🇵
Sunto-gun, Shizuoka, Japan
Japanese Red Cross Wakayama Medical Center /ID# 200643
🇯🇵
Wakayama-shi, Wakayama, Japan
Academisch Medisch Centrum /ID# 166927
🇳🇱
Amsterdam, Netherlands
Centrum Zdrowia MDM /ID# 200491
🇵🇱
Warszawa, Mazowieckie, Poland
Perm Clinical Center of the Federal Medical and Biological Agency /ID# 202990
🇷🇺
Perm, Permskiy Kray, Russian Federation
P.A. Bayandin Murmansk Regiona /ID# 169639
🇷🇺
Murmansk, Russian Federation
Semmelweis Egyetem /ID# 210167
🇭🇺
Budapest, Hungary
Magyar Honvedseg Egeszsegugyi Kozpont /ID# 201724
🇭🇺
Budapest, Hungary
Instituto de Investigaciones Aplicadas a la Neurociencias A.C. /ID# 207579
🇲🇽
Victoria de Durango, Durango, Mexico
Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 214470
🇦🇹
Salzburg, Austria
Klinicki bolnicki centar Sestre milosrdnice /ID# 205535
🇭🇷
Zagreb, Grad Zagreb, Croatia
Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 171013
🇪🇬
Alexandria, Egypt
Debreceni Egyetem Klinikai Kozpont /ID# 216419
🇭🇺
Debrecen, Hajdu-Bihar, Hungary
Bugat Pal Korhaz /ID# 201893
🇭🇺
Gyöngyös, Heves, Hungary
Szent Borbala Korhaz /ID# 209897
🇭🇺
Tatabanya, Komarom-Esztergom, Hungary
National Hospital Organization Takasaki General Medical Center /ID# 167127
🇯🇵
Takasaki-shi, Gunma, Japan
NHO Fukuyama Medical Center /ID# 167131
🇯🇵
Fukuyama-shi, Hiroshima, Japan
Hyogo College of Medicine College Hospital /Id# 165973
🇯🇵
Nishinomiya-shi, Hyogo, Japan
Yokkaichi Hazu Medical Center /ID# 167196
🇯🇵
Yokkaichi-shi, Mie, Japan
Tohoku University Hospital /ID# 167122
🇯🇵
Sendai-shi, Miyagi, Japan
Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 166010
🇯🇵
Kurashiki-shi, Okayama, Japan
Kinshukai Infusion Clinic /ID# 218872
🇯🇵
Osaka-shi, Osaka, Japan
Osaka Medical and Pharmaceutical University Hospital /ID# 206326
🇯🇵
Takatsuki-shi, Osaka, Japan
Tokyo Medical And Dental University Hospital /ID# 165965
🇯🇵
Bunkyo-ku, Tokyo, Japan
Pauls Stradins Clinical University Hospital /ID# 169519
🇱🇻
Riga, Latvia
WIP Warsaw IBD Point Profesor Kierkus /ID# 224301
🇵🇱
Warsaw, Mazowieckie, Poland
University Clinical Center Kragujevac /ID# 205859
🇷🇸
Kragujevac, Sumadijski Okrug, Serbia
Warrington and Halton Hospitals NHS Foundation Trust /ID# 209086
🇬🇧
Warrington, Cheshire West And Chester, United Kingdom
National Hepatology and Tropical Medicine Research Institute /ID# 170989
🇪🇬
Cairo, Egypt
Polyclinic and Daily Hospital Dr. Al-Tawil /ID# 217842
🇧🇦
Sarajevo, Bosnia and Herzegovina
Clinical Hospital Dubrava /ID# 171185
🇭🇷
Zagreb, Grad Zagreb, Croatia
Poliklinika Solmed /ID# 211519
🇭🇷
Zagreb, Grad Zagreb, Croatia
General Hospital of Athens Ippokratio /ID# 167045
🇬🇷
Athens, Attiki, Greece
Mohacsi Korhaz /ID# 209441
🇭🇺
Mohacs, Baranya, Hungary
CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 205547
🇭🇺
Encs, Borsod-Abauj-Zemplen, Hungary
Obudai Egeszsegugyi Centrum Kft. /ID# 201892
🇭🇺
Budapest, Pest, Hungary
Mercy University Hospital /ID# 206511
🇮🇪
Cork, Ireland
Nagoya City University Hospital /ID# 165970
🇯🇵
Nagoya shi, Aichi, Japan
Nagoya University Hospital /ID# 165969
🇯🇵
Nagoya-shi, Aichi, Japan
Kurume University Hospital /ID# 166012
🇯🇵
Kurume-shi, Fukuoka, Japan
Hiroshima University Hospital /ID# 166014
🇯🇵
Hiroshima-shi, Hiroshima, Japan
Yamagata University Hospital /ID# 200157
🇯🇵
Yamagata-shi, Yamagata, Japan
Digestive Disease Center Gastro /ID# 169508
🇱🇻
Riga, Latvia
Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 206936
🇱🇹
Kaunas, Lithuania
Vilnius University Hospital Santaros Klinikos /ID# 203286
🇱🇹
Vilnius, Lithuania
Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 170773
🇲🇾
Kuala Lumpur, Selangor, Malaysia
Universiti Sains Malaysia /ID# 200102
🇲🇾
Kelantan, Malaysia
School of Medicine University of Puerto Rico-Medical Science Campus /ID# 166771
🇵🇷
San Juan, Puerto Rico
LLC Novaya Klinika /ID# 206616
🇷🇺
Pyatigorsk, Stavropol Skiy Kray, Russian Federation
Clinical Hosp Center Zvezdara /ID# 168214
🇷🇸
Belgrade, Beograd, Serbia
Clinical Center Vojvodina /ID# 168213
🇷🇸
Novi Sad, Vojvodina, Serbia
Research Group /ID# 203179
🇨🇱
Santiago, Region Metropolitana De Santiago, Chile
M y F Estudios Clínicos /ID# 169984
🇨🇱
Santiago, Region Metropolitana Santiago, Chile
Hospital Clinico Universidad De Los Andes /ID# 207466
🇨🇱
Santiago, Chile
Hospital Universitario San Vic /ID# 200029
🇨🇴
Medellin, Colombia
National Liver Institute /ID# 170988
🇪🇬
Menoufiya, Egypt
Tzaneio general hospital of Piraeus /ID# 206433
🇬🇷
Piraeus, Attiki, Greece
General Hospital of Thessaloniki Hippokrateio /ID# 208825
🇬🇷
Thessaloniki, Greece
Debreceni Egyetem Kenezy Gyula Egyetemi Korhaz /ID# 201723
🇭🇺
Debrecen, Hungary
Pest Megyei Flor Ferenc Korhaz /ID# 206154
🇭🇺
Kistarcsa, Hungary
Tel Aviv Sourasky Medical Center /ID# 204877
🇮🇱
Tel Aviv-Yafo, Tel-Aviv, Israel
Assaf Harofeh Medical Center /ID# 204872
🇮🇱
Be'Er Ya'Akov, Israel
Hadassah Medical Center-Hebrew University /ID# 169928
🇮🇱
Jerusalem, Israel
Aichi Medical University Hospital /ID# 165971
🇯🇵
Nagakute-shi, Aichi, Japan
Toyohashi Municipal Hospital /ID# 200175
🇯🇵
Toyohashi-shi, Aichi, Japan
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 165960
🇯🇵
Sapporo-shi, Hokkaido, Japan
Kenseikai Dongo Hospital /ID# 208104
🇯🇵
Yamatotakada-shi, Nara, Japan
Osaka Metropolitan University Hospital /ID# 166015
🇯🇵
Osaka-shi, Osaka, Japan
Osaka University Hospital /ID# 169663
🇯🇵
Suita-shi, Osaka, Japan
GIRI Gastrointestinal Research Institute /ID# 166975
🇨🇦
Vancouver, British Columbia, Canada
Vistamed /ID# 208572
🇵🇱
Wroclaw, Dolnoslaskie, Poland
Centrum Medyczne Reuma Park /ID# 200490
🇵🇱
Warszawa, Mazowieckie, Poland
Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 170245
🇵🇹
Guimaraes, Braga, Portugal
Cabinet Particular Policlinic Algomed /ID# 167818
🇷🇴
Timișoara, Romania
Kazan State Medical University /ID# 169638
🇷🇺
Kazan, Tatarstan, Respublika, Russian Federation
Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 202997
🇷🇺
Stavropol, Stavropol Skiy Kray, Russian Federation
Clin Hosp Ctr Bezanijska Kosa /ID# 168750
🇷🇸
Belgrade, Beograd, Serbia
Allergy & Immunology (AIU) /ID# 171431
🇿🇦
Cape Town, Western Cape, South Africa
Olla-Med Clinic /ID# 208720
🇷🇺
Moscow, Russian Federation
University of Louisville /ID# 168572
🇺🇸
Louisville, Kentucky, United States
Endoscopic Research, Inc. /ID# 206136
🇺🇸
Orlando, Florida, United States
Omega Research Maitland, LLC /ID# 203481
🇺🇸
Orlando, Florida, United States
University of Louisville /ID# 165366
🇺🇸
Louisville, Kentucky, United States
Nola Research Works, LLC /ID# 164759
🇺🇸
New Orleans, Louisiana, United States
University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 164943
🇺🇸
Ann Arbor, Michigan, United States
Pharmacorp Clinical Trials /ID# 164916
🇺🇸
Charleston, South Carolina, United States
Wake Forest Baptist Medical Center /ID# 164908
🇺🇸
Winston-Salem, North Carolina, United States
Allen Whey Khye Lim Professional Corporation /ID# 168044
🇨🇦
Edmonton, Alberta, Canada
Box Hill Hospital /ID# 203736
🇦🇺
Box Hill, Victoria, Australia
United Medical Doctors /ID# 207449
🇺🇸
Los Alamitos, California, United States
Care Access Research /ID# 167767
🇺🇸
San Pablo, California, United States
Hospital Pablo Tobon Uribe /ID# 202404
🇨🇴
Medellín, Antioquia, Colombia
Fraser Clinical Trials Inc /ID# 166968
🇨🇦
New Westminster, British Columbia, Canada
The Jikei University Hospital /ID# 167130
🇯🇵
Minato-ku, Tokyo, Japan
Radboud Universitair Medisch Centrum /ID# 166928
🇳🇱
Nijmegen, Gelderland, Netherlands
Zuyderland Medisch Centrum /ID# 169700
🇳🇱
Heerlen, Limburg, Netherlands
Policlinico Universitario Campus Bio-Medico /ID# 168183
🇮🇹
Rome, Lazio, Italy
Kyorin University Hospital /ID# 165966
🇯🇵
Mitaka-shi, Tokyo, Japan
Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 207238
🇲🇽
Guadalajara, Jalisco, Mexico
Farmovs (Pty) Ltd /Id# 207535
🇿🇦
Bloemfontein, Free State, South Africa
Hospital Universitario de Navarra /ID# 202355
🇪🇸
Pamplona, Navarra, Spain
Erciyes University Medical Fac /ID# 171331
🇹🇷
Melikgazi, Kayseri, Turkey
Tuen Mun Hospital /ID# 171218
🇭🇰
Hong Kong, Hong Kong