Evaluation of Patients After Cardiac Surgery: Novel Ultrasound Parameters for Quantification of Renal Perfusion & Analysis of Phenylephrines' Effect on Invasive Haemodynamics and Echocardiographic Measures
Overview
- Phase
- Phase 4
- Intervention
- Phenylephrine
- Conditions
- Ultrasonography, Renal
- Sponsor
- Aarhus University Hospital
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Renal arterial resistive index (RI).
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
To investigate the influence of PEEP (Positive end-expiratory pressure), changes in preload (patient position) and changes in afterload (phenylephrine) on ultrasound measures of renal perfusion in patients after uncomplicated cardiac surgery.
To investigate the effects of phenylephrine on both invasive measures of the systemic- and pulmonary circulation and, secondarily, to assess the induced changes in echocardiographic indices of left- and right ventricular systolic- and diastolic function.
Investigators
Johan Fridolf Hermansen
Principal Investigator
Aarhus University Hospital
Eligibility Criteria
Inclusion Criteria
- •All patients ≥ 18 years scheduled for open elective cardiac surgery at the Department of Cardiothoracic \& Vascular Surgery, Aarhus University Hospital.
Exclusion Criteria
- •Insufficient ultrasonographic imaging of the kidneys
- •Known morphological kidney disease
- •Preoperative dialysis
- •Chronic atrial fibrillation
- •Planned mitral valve surgery
Arms & Interventions
All patients included
Intervention: Phenylephrine
All patients included
Intervention: Combination of PEEP and positioning
Outcomes
Primary Outcomes
Renal arterial resistive index (RI).
Time Frame: 75 minutes
The ratio SVR/PVR (systemic vascular resistance/pulmonary vascular resistance)
Time Frame: 75 minutes
Secondary Outcomes
- Transoesophageal measurement of left and right ventricular function 5(75 minutes)
- Renal venous impedance index.(75 minutes)
- Transoesophageal measurement of left and right ventricular function 1(75 minutes)
- Transoesophageal measurement of left and right ventricular function 6(75 minutes)
- Renal venous stasis index.(75 minutes)
- Portal vein pulsatility fraction.(75 minutes)
- Cardiac output(75 minutes)
- Arterial blood pressure, central venous pressure, pulmonary blood pressure, pulmonary capillary wedge pressure.(75 minutes)
- Transoesophageal measurement of left and right ventricular function 2(75 minutes)
- Transoesophageal measurement of left and right ventricular function 3(75 minutes)
- Transoesophageal measurement of left and right ventricular function 4(75 minutes)