Effect of multi-target transcranial current stimulation on cognition and pain.

Not Applicable

Recruiting

• Conditions: Pain; Neurological - Studies of the normal brain and nervous system; Mental Health - Studies of normal psychology, cognitive function and behaviour; Cognitive function

• Registration Number: ACTRN12620000240943
• Lead Sponsor: niversity of Otago

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-02-26
• Last Update Posted: 3 March 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

To be included in the study, participants must meet all of the following inclusion criteria:
•Capable of understanding and signing an informed consent form
•Cognitively healthy, as determined by age norms of Mini Mental Status Examination
•Age between 35 to 75 years on the day of the consent and
•Right dominant

Exclusion Criteria

Participants who meet any of the following conditions will be excluded:
•History of neurological disease
•History of epileptic seizures
•Unstable medical or psychiatric conditions
•Presence of any pacemaker or defibrillator
•Presence of any implant in head/neck
•Presence of any pain/ related condition
•Alcohol or substance abuse
•Presence of any peripheral neuropathy or vascular pathology

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Presence of any adverse events (e.g. itching, headache, fatigue). The severity of each symptom will be rated on a VAS scale.[Immediately before and after intervention];Neurocognitive tests (executive function, working memory) : Stroop task, Trail Making Test, Digit Span test[Immediately before and after intervention];Mechanical temporal summation: MTS will be assessed using a nylon monofilament (Semmes monofilament 6.65, 300 g). Brief ten repetitive contacts will be delivered at a rate of 1 Hz, externally cued by auditory stimuli. The participants will be asked to rate the level of pain experienced on the 11 point numeric pain rating scale (NPRS, 0=No pain to 100=Extreme pain) immediately after the first contact, and also to rate their greatest pain intensity after the 10th contact. Three trials will be conducted at the non-dominant wrist joint, and the average will be used for analysis. [Immediately before and after intervention]

Secondary Outcome Measures

Name	Time	Method
Electroencephalography patterns (whole brain activity and functional connectivity)[Immediately before and after intervention];Conditioned pain modulation procedure (CPM): This involves recording pressure to pain threshold over the non-dominant leg region (Tibialis anterior muscle) before and after the application of a conditioning stimulus (immersion of dominant hand, in a cold bath for a maximum of two minutes; maintained at ~5 degrees). A percent change score will be calculated.[Immediately before and after intervention];Change in the pressure to pain threshold (PPT) (KPa): A computerised, handheld digital algometer (AlgoMed; Medoc, Ramat Yishai, Israel) will be used to measure three trials of PPT over the non-dominant wrist, and the average of three trials will be used for analysis. [Immediately before and after intervention]