Transdiagnostic study of Adverse Childhood Experiences in people with mental health problems

Conditions: DSM-5: 300.4 Persistent depressive disordersICD-11: 6B41 Complex post-traumatic stress disorder
F60.31
F45
Recurrent depressive disorder
F33
F43.1
Post-traumatic stress disorder
Somatoform disorders

Registration Number: DRKS00034621

Lead Sponsor: MU Klinikum, Klinik für Psychiatrie und Psychotherapie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 550

Inclusion Criteria

We will include participants with sufficient German language skills to perform all questionnaires, interviews and introductions of the behavioral paradigm. Patients have to meet diagnostic criteria of one of the following main diagnoses according to the DSM-5: Diagnosis of a BPD (301.83), PDD (300.4, 296.2x, 296.3x, 296.3x), cPTSD (309.9), ED (296.xx) or SSD (300.82). Healthy controls have to not fulfill a psychiatric disorder assessed within a screening.

Exclusion Criteria

Clinical participants will be excluded if fulfilling DSM-5 criteria of an active substance-dependency (abstinence shorter than 6 months), a psychotic disorder or a bipolar I or II disorder or acute suicidality (as main or comorbid diagnosis). Participants will be screened and diagnosed by a trained clinician based on the DSM-5 criteria (SCID-5-CV and SCID-5-PD interview). All Individuals will be excluded if having a current or past somatic or neurological disorders with effects on the brain or if currently pregnant. Non-clinical participants will be excluded when having a history of a psychiatric disorder or a psychotherapeutic/psychopharmacological intervention within the last 10 years (reviewed by telephone screening and psychometric assessments). Participants with a regular (daily) current intake of benzodiazepines will be excluded due to confounding aspects for the experimental cyberball paradigm and the psychometric questionnaires.

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Identification of adverse childhood experiences clusters (ACE clusters) and cumulative ACE risk across rejection sensitivity (RS) outcome. Behavioral, affective, pneurophysiological and neuroendocrinological responses to social response to social exclusion.

Secondary Outcome Measures

Name	Time	Method
Differences in disorder-specific symptoms (depression, BPD, kPTBS, SSD), traumatization, loneliness, aggression, social network, resilience, attachment style, mentalization, DSM-5 personality pathology, quality of life, interpersonal problems, emotion regulation, and alterations in oxytocin system depending on ACE and RS. <br>Naturalistic longitudinal study of clinical and biological predictors, mediators and moderators of 10-week disorder-specific psychotherapy (CBASP, DBT).