Postoperative Delirium: a Complex Prediction Model in Patients Undergoing Major Abdominal Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Postoperative Delirium
- Sponsor
- Institutul Regional de Gastroenterologie & Hepatologie Prof. dr. Octavian Fodor
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Prediction model for postoperative delirium (POD) in major abdominal surgery
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The study targets postoperative delirium in patients undergoing major abdominal surgery, with the aim to evaluate the functional baseline and proteomics implicated in pathogenesis, prevention strategies (such as anesthesia depth monitoring) and incidence in certain population groups.
Investigators
Mara Sonia Mihaescu
Principal Investigator, PhD Student
Institutul Regional de Gastroenterologie & Hepatologie Prof. dr. Octavian Fodor
Eligibility Criteria
Inclusion Criteria
- •ASA risk I-III;
- •patients undergoing complex digestive surgery, such as esophagectomy, total gastrectomy, hemicolectomy, cephalic duodenopancreatectomy, hepatic resection.
Exclusion Criteria
- •the impossibility of obtaining the patient's consent/his decisional incapacity;
- •patients who underwent neurosurgery for cerebrospinal lesions / cardiac surgery under cardiopulmonary bypass;
- •prediagnosed senile/vascular/mixed dementia.
Outcomes
Primary Outcomes
Prediction model for postoperative delirium (POD) in major abdominal surgery
Time Frame: 3-4 years
Developing an accesible algorithm to anticipate the occurence of postoperative delirium, based on functional baseline and proteomics, in adult patients subjected to major abdominal surgical interventions. This includes investigating a correlation between a set of risk factors, a panel of biomarkers and the occurrence of postoperative delirium in the enrolled patients, respectively.
Secondary Outcomes
- Postoperative delirium incidence in surgical patients - subgroup - communism survivors(during ICU hospitalization)
- Postoperative delirium incidence in surgical patients - subgroup - patients with no relatives/visitors(during ICU hospitalization)
- Anesthesia depth monitoring and the incidence of postoperative delirium(0-4 days postoperatively)
- Postoperative delirium incidence in surgical patients in the Intensive Care Unit (ICU) setting(during ICU hospitalization)