Postoperative Delirium: a Complex Prediction Model in Patients Undergoing Major Abdominal Surgery
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Prediction model for postoperative delirium (POD) in major abdominal surgery
研究概览
简要总结
The study targets postoperative delirium in patients undergoing major abdominal surgery, with the aim to evaluate the functional baseline and proteomics implicated in pathogenesis, prevention strategies (such as anesthesia depth monitoring) and incidence in certain population groups.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA risk I-III;
- •patients undergoing complex digestive surgery, such as esophagectomy, total gastrectomy, hemicolectomy, cephalic duodenopancreatectomy, hepatic resection.
排除标准
- •the impossibility of obtaining the patient's consent/his decisional incapacity;
- •patients who underwent neurosurgery for cerebrospinal lesions / cardiac surgery under cardiopulmonary bypass;
- •prediagnosed senile/vascular/mixed dementia.
结局指标
主要结局
Prediction model for postoperative delirium (POD) in major abdominal surgery
时间窗: 3-4 years
Developing an accesible algorithm to anticipate the occurence of postoperative delirium, based on functional baseline and proteomics, in adult patients subjected to major abdominal surgical interventions. This includes investigating a correlation between a set of risk factors, a panel of biomarkers and the occurrence of postoperative delirium in the enrolled patients, respectively.
次要结局
- Postoperative delirium incidence in surgical patients - subgroup - communism survivors(during ICU hospitalization)
- Postoperative delirium incidence in surgical patients - subgroup - patients with no relatives/visitors(during ICU hospitalization)
- Anesthesia depth monitoring and the incidence of postoperative delirium(0-4 days postoperatively)
- Postoperative delirium incidence in surgical patients in the Intensive Care Unit (ICU) setting(during ICU hospitalization)
研究者
Mara Sonia Mihaescu
Principal Investigator, PhD Student
Institutul Regional de Gastroenterologie & Hepatologie Prof. dr. Octavian Fodor