Clinical Outcomes Of Modified Del Nido Cardioplegia In Adult And Pediatric Cardiac Surgery; A Multicentered Cross-Sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- the Bypass time
研究概览
简要总结
"Introduction: Modern cardiac surgery prioritizes myocardial protection, incorporating various strategies including cardioplegia to preserve heart function during surgery. The Del Nido (DN) cardioplegia solution, initially for pediatric use, shows promise in adult surgeries due to its longer protection duration and reduced re-dosing needs. However, its efficacy in adults remains under-researched.
详细描述
This study aims to evaluate the clinical outcomes of modified Del Nido cardioplegia in adult and pediatric cardiac surgeries, comparing intraoperative and postoperative metrics to provide evidence on its efficacy and safety.
To assess the clinical outcomes of modified Del Nido cardioplegia in cardiac surgeries across different age groups, focusing on myocardial protection, hemodynamic stability, surgical outcomes, recovery, and complications.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 1 Year 至 60 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All Pediatric patients with congenital heart diseases.
- •Individuals who are capable of giving their informed permission;
- •Stable patients undergoing surgical procedures that involve cardiopulmonary bypass and cardiac arrest;
- •isolated CABG surgery, or simultaneous CABG;
- •isolated single-valve surgery or multiple value procedures.
排除标准
- •Previous cardiac surgery
- •Patients with preoperative inotropic pharmacologic support
- •Patients receiving preoperative mechanical circulatory support,
- •Patients with an implanted pacemaker or implantable cardioverter-defibrillator,
- •Patients undergoing cardiac surgical procedures
- •Patients who underwent off-pump or beating heart CABGs
- •Ventilation for the night was scheduled because of severe pulmonary arterial hypertension.
- •mediastinal drain causing a delay in extubation, or the need to reopen for bleeding or tamponade.
结局指标
主要结局
the Bypass time
时间窗: up to 12 Months
postoperative mortality
时间窗: 12 Months
次要结局
未报告次要终点
研究者
Muhammad Naveed Babur
Principal Investigator
Superior University